The Clinical Characteristics and Outcomes of COVID-19 Patients with Pre-Existing Thyroid Dysfunction: A Nationwide Study

被引：2

作者：

Sahin, Mustafa ^{[1
]}

Demirci, Ibrahim ^{[2
,3
]}

Haymana, Cem ^{[2
,3
]}

Tasci, Ilker ^{[2
,4
]}

Emral, Rifat ^{[1
]}

Cakal, Erman ^{[5
]}

Unluturk, Ugur ^{[6
]}

Satman, Ilhan ^{[7
]}

Demir, Tevfik ^{[8
]}

Ata, Naim ^{[9
]}

Ertugrul, Derun ^{[10
]}

Atmaca, Aysegul ^{[11
]}

Salman, Serpil ^{[12
]}

Sahin, Ibrahim ^{[13
]}

Dagdelen, Selcuk ^{[5
]}

Celik, Osman ^{[14
]}

Caglayan, Murat ^{[15
]}

Sonmez, Alper ^{[2
,3
]}

机构：

[1] Ankara Univ, Fac Med, Dept Endocrinol & Metab, Ankara, Turkey

[2] Univ Hlth Sci, Gulhane Fac Med, Ankara, Turkey

[3] Univ Hlth Sci, Gulhane Training & Res Hosp, Dept Endocrinol & Metab, Ankara, Turkey

[4] Univ Hlth Sci, Gulhane Training & Res Hosp, Dept Internal Med, Ankara, Turkey

[5] Univ Hlth Sci, Diskapi Yildirim Beyazit Training & Res Hosp, Fac Med, Dept Endocrinol & Metab, Ankara, Turkey

[6] Hacettepe Univ, Fac Med, Dept Endocrinol & Metab, Ankara, Turkey

[7] Istanbul Univ, Fac Med, Dept Endocrinol & Metab, Istanbul, Turkey

[8] Dokuz Eylul Univ, Fac Med, Dept Endocrinol & Metab, Ankara, Turkey

[9] Minist Hlth, Dept Strategy Dev, Ankara, Turkey

[10] Univ Hlth Sci, Kecioren Training & Res Hosp, Fac Med, Dept Endocrinol & Metab, Ankara, Turkey

[11] Ondokuz Mayis Univ, Fac Med, Dept Endocrinol & Metab, Samsun, Turkey

[12] Med Clin, Dept Endocrinol & Metab, Istanbul, Turkey

[13] Inonu Univ, Fac Med, Dept Endocrinol & Metab, Malatya, Turkey

[14] Publ Hosp Gen Directorate, Minist Hlth, Ankara, Turkey

[15] Ankara Prov Hlth Directorate, Ankara, Turkey

来源：

HORMONE AND METABOLIC RESEARCH | 2023年 / 55卷 / 01期

关键词：

thyroid dysfunction; hyperthyroidism; TSH; COVID-19; mortality; ICU admission; EXCESS MORTALITY; HYPERTHYROIDISM; HYPOTHYROIDISM; DISEASE; COHORT;

D O I：

10.1055/a-1971-8781

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

To which extent the pre-existing hypothyroidism or hyperthyroidism has an impact on coronavirus infection 2019 (COVID-19) outcomes remains unclear. The objective of this study was to evaluate COVID-19 morbidity and mortality in patients with pre-existing thyroid dysfunction. A retrospective cohort of patients with a polymerase chain reaction (PCR)-con?rmed COVID-19 infection (n=14 966) from March 11 to May 30, 2020, was established using the database of the Turkish Ministry of Health. We compared the morbidity and mortality rates of COVID-19 patients with pre-existing hypothyroidism (n=8813) and hyperthyroidism (n=1822) to those patients with normal thyroid function (n=4331). Univariate and multivariate regression analyses were performed to identify the factors associated with mortality. Mortality rates were higher in patients with hyperthyroidism (7.7%) and hypothyroidism (4.4%) than those with normal thyroid function (3.4%) (p < 0.001 and p=0.008, respectively). Pre-existing hyperthyroidism was significantly associated with an increased risk of mortality (OR 1.54; 95% CI, 1.02-2.33; p=0.042) along with advanced age, male gender, lymphopenia and chronic kidney disease (p < 0.001 for all). Although a potential trend was noted, the association between pre-existing hypothyroidism and mortality was not significant (OR 1.36; 95% CI, 0.99-1.86; p=0.055). In conclusion, this study showed an association between pre-existing hyperthyroidism with higher COVID-19 mortality. A potential trend towards increased mortality was also observed for hypothyroidism. The risk was more pronounced in patients with hyperthyroidism.

引用

页码：25 / 30

页数：6

共 28 条

[1] Elevated TSH in adults treated for hypothyroidism is associated with increased mortality [J].