TrkB/BDNF signaling pathway and its small molecular agonists in CNS injury

被引：35
作者：
Wang, Yujin [1 ,2 ,3 ]
Liang, Jing [1 ,2 ,4 ]
Xu, Boyu [1 ,2 ,3 ]
Yang, Jin [1 ,2 ,3 ]
Wu, Zhourui [1 ,2 ]
Cheng, Liming [1 ,2 ]
机构：
[1] Tongji Univ, Sch Med, Tongji Hosp, Div Spine Surg,Dept Orthoped, Shanghai 200065, Peoples R China
[2] Tongji Univ, Minist Educ, Key Lab Spine & Spinal cord Injury Repair & Regene, Shanghai 200072, Peoples R China
[3] Tongji Univ, Med Sch, Shanghai 200433, Peoples R China
[4] Tongji Univ, Sch Stomatol, Shanghai 200072, Peoples R China
来源：
LIFE SCIENCES | 2024年 / 336卷
基金：
中国国家自然科学基金;
关键词：
Brain-derived neurotrophic factor; Tropomyosin-related kinase receptor B; Traumatic brain injury; Spinal cord injury; Small molecular TrkB agonists; N-ACETYL SEROTONIN; BDNF MESSENGER-RNA; TRKB NEUROTROPHIN RECEPTOR; TRUNCATED TRKB; SYNAPTIC PLASTICITY; COGNITIVE IMPAIRMENTS; ANTIDEPRESSANT DRUGS; HIPPOCAMPAL-NEURONS; CELL-PROLIFERATION; NEUROPATHIC PAIN;
D O I：
10.1016/j.lfs.2023.122282
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
As one of the most prevalent neurotrophic factors in the central nervous system (CNS), brain-derived neurotrophic factor (BDNF) plays a significant role in CNS injury by binding to its specific receptor Tropomyosinrelated kinase receptor B (TrkB). The BDNF/TrkB signaling pathway is crucial for neuronal survival, structural changes, and plasticity. BDNF acts as an axonal growth and extension factor, a pro-survival factor, and a synaptic modulator in the CNS. BDNF also plays an important role in the maintenance and plasticity of neuronal circuits. Several studies have demonstrated the importance of BDNF in the treatment and recovery of neurodegenerative and neurotraumatic disorders. By undertaking in-depth study on the mechanism of BDNF/TrkB function, important novel therapeutic strategies for treating neuropsychiatric disorders have been discovered. In this review, we discuss the expression patterns and mechanisms of the TrkB/BDNF signaling pathway in CNS damage and introduce several intriguing small molecule TrkB receptor agonists produced over the previous several decades.
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页数：21
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