Analysis of prognosis in different subtypes of invasive lobular carcinoma using the Japanese National Cancer Database-Breast Cancer Registry

被引：10

作者：

Adachi, Yayoi ^{[1
,2
]}

Asaga, Sota ^{[3
]}

Kumamaru, Hiraku ^{[4
]}

Kinugawa, Naoko ^{[4
]}

Sagara, Yasuaki ^{[5
]}

Niikura, Naoki ^{[6
]}

Jinno, Hiromitsu ^{[7
]}

Saji, Shigehira ^{[8
]}

Toi, Masakazu ^{[9
]}

机构：

[1] Aichi Canc Ctr, Dept Breast Oncol, 1 1 Kanokoden,Chikusa ku, Nagoya, Aichi 4648681, Japan

[2] Univ Texas Southwestern Med Ctr, Dept Pathol, 5323 Harry Hines Blvd, Dallas, TX 75206 USA

[3] Keiyu Hosp, Dept Surg, 3 7 3 Minatomirai, Yokohama, Kanagawa 2208521, Japan

[4] Univ Tokyo, Dept Healthcare Qual Assessment, 7 3 1 Hongo,Bunkyo ku, Tokyo 1138655, Japan

[5] Social Med Cooperat Hakuaikai, Dept Breast Surg Oncol, 3 31 Matsubara cho, Kagoshima 8920833, Japan

[6] Tokai Univ, Dept Breast & Endocrine Surg, Sch Med, 143,Shimokasuya, Isehara, Kanagawa 2591193, Japan

[7] Teikyo Univ, Dept Surg, Sch Med, 2-11-1 Kaga,Itabashi Ku, Tokyo 1738606, Japan

[8] Fukushima Med Univ, Dept Med Oncol, 1 Hikariga oka, Fukushima 9601295, Japan

[9] Kyoto Univ, Dept Breast Surg, Grad Sch Med, 54 Kawaracho,Shogoin,Sakyo ku, Kyoto 6068507, Japan

来源：

BREAST CANCER RESEARCH AND TREATMENT | 2023年 / 201卷 / 03期

关键词：

Invasive lobular carcinoma; Luminal; Prognosis; Chemotherapy; RELATIVE EFFECTIVENESS; CHEMOTHERAPY; GRADE;

D O I：

10.1007/s10549-023-07022-x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

PurposeMany studies have shown that the prognosis of invasive lobular carcinoma (ILC) is better than that of invasive ductal carcinoma (IDC). However, both disorders exhibit different prognoses according to molecular subtype, and the prognosis of ILC subtypes might depend on their hormone receptor positivity rate. This study clarified the prognosis of ILC and IDC in each subtype and examined the effectiveness of adjuvant chemotherapy (CT) in luminal ILC.MethodsWe planned the analysis using data from the Breast Cancer Registry in Japan. Because it was presumed that there are differences in characteristics between ILC and IDC, we created matched cohorts using exact matching to compare their prognoses. We compared the prognosis of ILC and IDC for each subtype. We also compared the prognosis of luminal ILC between the CT and non-CT groups.ResultsFor all subtypes, the disease-free survival (DFS) and overall survival (OS) of ILC were poorer than those of IDC. In the analysis by each subtype, no statistically significant difference was found in DFS and OS in luminal human epidermal growth factor 2 (HER2), HER2, and triple-negative cohorts; however, luminal ILC had significantly poorer DFS and OS than luminal IDC. The CT effects on the prognosis of luminal ILC were greater in more advanced cases.ConclusionLuminal ILC had a poorer prognosis than luminal IDC, contributing to the worse prognosis of ILC than that of IDC in the overall cohort. Different therapeutic approaches from luminal IDC are essential for a better prognosis of luminal ILC.

引用

页码：397 / 408

页数：12

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