Complete hematologic response after belinostat treatment and allogeneic stem cell transplantation for multiple relapsed/refractory angioimmunoblastic T-cell lymphoma: A case report

被引：1

作者：

Camus, Vincent ^{[1
,5
]}

Etancelin, Pascaline ^{[2
]}

Drieux, Fanny ^{[3
]}

Veresezan, Elena-Liana ^{[3
]}

Picquenot, Jean-Michel ^{[3
]}

Penther, Dominique ^{[2
]}

Viennot, Mathieu ^{[4
]}

Ruminy, Philippe ^{[4
]}

Contentin, Nathalie ^{[1
]}

Lemasle, Emilie ^{[1
]}

Lepretre, Stephane ^{[1
]}

Dubois, Sydney ^{[1
]}

Penichoux, Juliette ^{[1
]}

Stamatoullas, Aspasia ^{[1
]}

Zduniak, Alexandra ^{[1
]}

Lanic, Helene ^{[1
]}

Jardin, Fabrice ^{[1
]}

机构：

[1] Ctr Henri Becquerel, Dept Hematol, Rouen, France

[2] Ctr Henri Becquerel, Dept Genet Oncol, Rouen, France

[3] Ctr Henri Becquerel, Dept Pathol, Rouen, France

[4] Ctr Henri Becquerel, INSERM U1245, Rouen, France

[5] Ctr Henri Becquerel, Dept Hematol, Rue Amiens, F-76038 Rouen 1, France

来源：

CLINICAL CASE REPORTS | 2023年 / 11卷 / 06期

关键词：

allogenic stem cell transplantation; belinostat; complete response; HDAC inhibitor; nTFHL-AI; PTCL;

D O I：

10.1002/ccr3.7623

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Key Clinical MessageThis case report highlights the potential of belinostat for the treatment of relapsed/refractory peripheral T-cell lymphomas, for which effective therapies are still scarce. Peripheral T-cell lymphomas have an aggressive disease course associated with poor outcomes. We report a young patient with highly pretreated relapsed/refractory nodal follicular helper T-cell lymphoma (angioimmunoblastic-type [nTFHL-AI]), who successfully received an allogeneic stem cell transplantation following belinostat therapy. The complete hematologic response achieved has lasted more than 2 years.

引用

页数：10

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