Factors related to mortality in critically ill histoplasmosis: a multicenter retrospective study in Guadeloupe and French Guyana

被引:3
作者
Camous, Laurent [1 ,9 ]
Surel, Arthur [1 ]
Kallel, Hatem [2 ]
Nicolas, Muriel [3 ]
Martino, Frederic [1 ,4 ,5 ]
Valette, Marc [1 ]
Demoule, Alexandre [6 ,7 ]
Pommier, Jean-David [1 ,8 ]
机构
[1] Antilles Guyane Univ, Guadeloupe Teaching Hosp, Intens Care Unit, Chemin Chauvel, Les Abymes, France
[2] Cayenne Hosp, Intens Care Unit, Papaichton, French Guyana, France
[3] Antilles Guyane Univ, Guadeloupe Teaching Hosp, Mycol Dept, Chemin Chauvel, Les Abymes, France
[4] Univ Paris, F-75015 Paris, France
[5] Univ Antilles, INSERM, BIGR, F-75015 Paris, France
[6] Sorbonne Univ, Neurophysiol Resp Expt & Clin UMRS1158, INSERM, F-75005 Paris, France
[7] Sorbonne Univ, Dept R3S, Serv Med Intens & Reanimat, Grp Hosp Univ,AP HP, Site Pitie Salpetriere, F-75013 Paris, France
[8] Inst Pasteur Guadeloupe, F-97139 Les Abymes, France
[9] CHU Guadeloupe, Reanimat Med & Chirurg, F-97139 Les Abyme, France
关键词
Histoplasmosis; Intensive care unit; Fungal infection; Immunodeficiency; AIDS; ACQUIRED-IMMUNODEFICIENCY-SYNDROME; FUNGAL-INFECTIONS; EPIDEMIOLOGY; EXPERIENCE;
D O I
10.1186/s13613-023-01128-7
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
PurposeTo describe clinical and biological features and the outcomes of patients admitted for histoplasmosis in two intensive care units (ICU) in French Guyana and in the French West Indies (Guadeloupe).MethodsAll patients admitted to these two ICUs for culture-proven histoplasmosis between January 2014 to August 2022 were included in the study. Using univariate and multivariate analysis, we assessed risk factors at ICU admission that were associated with death.ResultsForty patients were included (65% men). Median age was 56 years and simplified acute physiologic score (SAPS) II was 65. HIV was found in 58%, another immunodeficiency was identified in 28%, and no underlying immunodeficiency could be identified in 14% of patients. Within the first 24 h of ICU admission, 85% of patients had acute respiratory failure, 78% had shock, 30% had coma, and 48% had hemophagocytic lymphohistiocytosis. Mechanical ventilation was instituted in 78% of patients and renal replacement therapy in 55%. The 30-day mortality was 53%. By multivariate analysis, factors independently associated with 30-day mortality were SOFA score (odds ratio [OR] 1.5, 95% confidence interval [CI] [1.1-2.1]), time between symptom onset and treatment per day (OR 1.1, 95% CI 1.0-1.1), and hemophagocytic lymphohistiocytosis (OR 6.4, 95% CI 1.1-47.5).ConclusionHistoplasmosis requiring ICU admission is a protean disease with multiple and severe organ involvement. Immunodeficiency is found in most patients. The prognosis remains severe despite appropriate treatment and is worsened by late treatment initiation.
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页数:9
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