Systemic reactogenicity following homologues and heterologous prime-boost AZD1222 and BNT162b2 COVID-19 vaccination of 2862 healthcare workers compared with an unvaccinated population

被引：0

作者：

Tabatabaeifar, Sorosh ^{[1
]}

Vestergaard, Jesper M. ^{[1
]}

Wurtz, Else T. ^{[1
]}

Hansen, Karoline K. ^{[1
]}

Nielsen, Kent J. ^{[2
]}

Schlunssen, Vivi ^{[3
]}

Kolstad, Henrik A. ^{[1
,4
]}

机构：

[1] Aarhus Univ Hosp, Danish Ramazzini Ctr, Dept Occupat Med, Aarhus, Denmark

[2] Goedstrup Hosp, Danish Ramazzini Ctr, Dept Occupat Med, Herning, Denmark

[3] Aarhus Univ, Danish Ramazzini Ctr, Dept Publ Hlth Environm Work & Hlth, Aarhus, Denmark

[4] Aarhus Univ, Dept Clin Med, Aarhus, Denmark

来源：

VACCINE: X | 2023年 / 13卷

关键词：

COVID-19; vaccine; Systemic reactogenicity; Vaccine safety; Cohort study; Healthcare workers;

D O I：

10.1016/j.jvacx.2023.100280

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

During spring 2021, AZD1222 and BNT162b2 were used as prime and BNT162b2 as booster COVID-19 vaccines in Denmark. We obtained self-reported information on systemic reactogenicity day-by-day during two weeks for 2862 healthcare workers vaccinated with heterologous AZD1222 + BNT162b2 or homologous BNT162b2 + BNT162b2 regimens and compared prevalences of symptoms with unvaccinated healthcare workers. We found comparable systemic reactogenicity during the first week in the two vaccine regimens and no reactogenicity during the second week. Most of the symptoms returned to a level equal to the control population four days after booster vaccination.(c) 2023 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

引用

页数：4

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