Aeroallergen-related Diseases Predate the Diagnosis of Inflammatory Bowel Disease

被引:8
作者
Alenezy, Namarik [1 ,2 ]
Nugent, Zoann [2 ,3 ]
Herman, Sari [2 ,4 ]
Zaborniak, Karver [1 ]
Ramsey, Clare D. [1 ]
Bernstein, Charles N. [1 ,2 ]
机构
[1] Univ Manitoba, Max Rady Coll Med, Rady Fac Hlth Sci, Dept Internal Med, Winnipeg, MB, Canada
[2] Univ Manitoba, Univ Manitoba IBD Clin & Res Ctr, Rady Fac Hlth Sci, Winnipeg, MB, Canada
[3] Canc Care Manitoba, Winnipeg, MB, Canada
[4] North York Med Grp, Toronto, ON, Canada
关键词
GLOBAL BURDEN; ASTHMA; PREVALENCE;
D O I
10.1093/ibd/izac184
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Objective: This study aimed to determine whether having a diagnosis of asthma or allergic rhinitis (AR) increased the risk of being diagnosed with inflammatory bowel disease (IBD) and whether there was increased incidence of these diseases after a diagnosis of IBD. Design: This is a retrospective, historical cohort-based study. We used the administrative data of Manitoba Health and the population-based University of Manitoba IBD Epidemiology Database. We used numbers of prescriptions for drugs used to treat asthma and to treat AR to identify diagnoses of asthma and AR, respectively. We calculated relative risks (RRs) to assess incidence of IBD compared with matched controls after diagnoses of asthma and AR and hazard ratios to determine the incidence of asthma and AR after IBD diagnosis. Results: Compared with controls, a diagnosis of asthma or AR preceding a diagnosis of IBD was increased in cases (RR, 1.62; 95% confidence interval [CI], 1.50-1.75; and RR, 2.10; 95% CI, 1.97-2.24) with a similar outcome by subtype of IBD (Crohn's disease vs ulcerative colitis) and by sex. On sensitivity analysis, diagnoses of asthma or AR were comparable when considering at least 5, 10, 15 or 20 drug prescriptions. Persons with IBD were more likely to develop asthma or AR than controls after being diagnosed with IBD (hazard ratio for asthma, 1.31, 95% CI, 1.181.45; and hazard ratio for AR, 2.62, 95% CI, 2.45-2.80). Conclusions: The association between asthma, AR, and IBD suggest the possibility that whatever triggers the onset of these atopic diseases may trigger the onset of IBD as well, and aeroallergens are plausible culprits. Lay Summary This study demonstrates that a preexisting diagnosis of asthma or allergic rhinitis is associated with an increased risk of subsequently developing IBD. These data reinforce the importance of considering that gastrointestinal complaints in patients with asthma and allergic rhinitis may reflect a possible diagnosis of IBD. It also raises the possibility that aeroallergens may be environmental cause(s) of IBD.
引用
收藏
页码:1073 / 1079
页数:7
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