Strategies for Preventing Esophageal Stenosis After Endoscopic Submucosal Dissection and Progress in Stem Cell-Based Therapies

被引:0
作者
Ye, Shujun [1 ]
Hu, Jingjing [1 ]
Zhang, Daxu [1 ]
Zhao, Shuo [1 ]
Shi, Xiaonan [1 ]
Li, Weilong [1 ]
Wang, Jingyi [1 ]
Guan, Weiping [2 ,3 ]
Yan, Li [1 ,3 ]
机构
[1] Chinese Peoples Liberat Army Gen Hosp, Med Ctr 2, Dept Geriatr Gastroenterol, Beijing 100853, Peoples R China
[2] Chinese Peoples Liberat Army Gen Hosp, Med Ctr 2, Dept Geriatr Neurol, Beijing 100853, Peoples R China
[3] Chinese Peoples Liberat Army Gen Hosp, Natl Clin Res Ctr Geriatr Dis, Beijing 100853, Peoples R China
关键词
stem cells; ESD; esophageal stenosis; regenerative medicine; ACELLULAR DERMAL MATRIX; REGENERATIVE MEDICINE; STRICTURE PREVENTION; MUCOSAL RESECTION; ORAL PREDNISOLONE; BALLOON DILATION; BOTULINUM TOXIN; SHEETS; INJECTION; CANCER;
D O I
10.1089/ten.teb.2023.0316
中图分类号
Q813 [细胞工程];
学科分类号
摘要
Endoscopic submucosal dissection (ESD) has been widely used in the early neoplasia of the esophagus. However, postoperative esophageal stenosis is a big problem, particularly when a large circumferential proportion of esophageal mucosa is resected. Currently, there are several methods available to prevent esophageal stenosis after ESD, including steroid administration, esophageal stent implantation, and endoscopic balloon dilation (EBD). However, the therapeutic effects of these are not yet satisfactory. Stem cell-based therapies has shown promising potential in reconstructing tissue structure and restoring tissue function. In this study, we discussed the current strategies for preventing esophageal stenosis after ESD and perspectives of stem cell-based therapies for the prevention of esophageal stenosis. Impact statement Currently, there are no satisfactory means of treating esophageal stenosis after endoscopic submucosal dissection (ESD), but stem cell-based treatment methods and regenerative medicine show great potential in this regard. They may be the future solution for treating esophageal stenosis after ESD. Therefore, we have reviewed recent research literature on stem cells and regenerative medicine in the prevention of esophageal stenosis after ESD, summarized the applications of stem cell therapy and regenerative medicine in this field, and presented future prospects.
引用
收藏
页码:522 / 529
页数:8
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