Risk Factors for Treatment Failure in Neonates With Skin and Soft Tissue Infection: A Retrospective Cohort Study

被引：1

作者：

Patel, Purva ^{[1
]}

Foster, Catherine E. ^{[2
,3
]}

Stimes, Grant ^{[2
,3
,4
]}

Lee, Su Rin ^{[1
,4
]}

Wallace, Sowdhamini S. ^{[1
,5
]}

机构：

[1] Baylor Coll Med, Texas Childrens Hosp, Div Pediat Hosp Med, Houston, TX USA

[2] Baylor Coll Med, Texas Childrens Hosp, Dept Infect Dis, Houston, TX USA

[3] Texas Childrens Hosp, Baylor Coll Med, Dept Pediat, Houston, TX USA

[4] Baylor Coll Med, Texas Childrens Hosp, Dept Pharm, Houston, TX USA

[5] Baylor Coll Med, Texas Childrens Hosp, Div Pediat Hosp Med, 1102 Bates St FC 1860, Houston, TX 77030 USA

来源：

CLINICAL PEDIATRICS | 2024年 / 63卷 / 05期

关键词：

neonates; infants; skin and soft tissue infection; Staphylococcus aureus; perirectal abscess; STAPHYLOCOCCUS-AUREUS INFECTIONS; PERIANAL ABSCESS; MANAGEMENT; CHILDREN; INFANTS; FISTULA; PHARMACOKINETICS; ABSORPTION; PRETERM; SAFETY;

D O I：

10.1177/00099228231189132

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

We aimed to describe the frequency of treatment failure and associated risk factors for treatment failure amongst neonates with skin and soft tissue infections (SSTIs). We conducted a retrospective cohort study of neonates 0 to 28 days old with uncomplicated SSTIs presenting to the emergency department of a quaternary care children's hospital from 2009 to 2017. Data were collected via chart review. Skin and soft tissue infections included the following: cellulitis, abscess, mastitis, perirectal SSTI, carbuncle, and furuncle. Of the 202 neonates in the study, most were term, afebrile with mastitis, or perirectal SSTI. Treatment failure occurred in 8% (17/202) of neonates receiving oral antibiotics; 10 of these neonates had perirectal SSTIs and 2 had clindamycin and methicillin-resistant Staphylococcus aureus. Neonates with treatment failure had increased odds of having perirectal SSTIs (odds ratio [OR] = 4.08, 95% confidence interval [CI] = 1.46-11.31). Further studies are needed to identify strategies to prevent treatment failure in neonates with perirectal SSTIs.

引用

页码：689 / 696

页数：8

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