From signal transduction to protein toxins-a narrative review about milestones on the research route of C. difficile toxins

被引：7
作者：
Aktories, Klaus [1 ]
机构：
[1] Univ Freiburg, Fac Med, Inst Expt & Clin Pharmacol & Toxicol, Albertstr 25, D-79104 Freiburg, Germany
来源：
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY | 2023年 / 396卷 / 02期
关键词：
G proteins; Bacterial protein toxins; C. difficile toxin TcdB; C. difficile ADP-ribosyltransferase CDT; Pseudomembranous colitis; Toxin receptors; Toxin up-take; STIMULATED LIPOPROTEIN RECEPTOR; ISLET-ACTIVATING PROTEIN; BOTULINUM C2 TOXIN; CLOSTRIDIUM-DIFFICILE; RHO-GTPASES; GLUCOSYLATING TOXINS; FRIZZLED PROTEINS; ESCHERICHIA-COLI; STRUCTURAL BASIS; BINDING PROTEIN;
D O I：
10.1007/s00210-022-02300-9
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Selected findings about Clostridioides difficile (formerly Clostridium difficile) toxins are presented in a narrative review. Starting with a personal view on research about G proteins, adenylyl cyclase, and ADP-ribosylating toxins in the laboratory of Gunter Schultz in Heidelberg, milestones of C. difficile toxin research are presented with the focus on toxin B (TcdB), covering toxin structure, receptor binding, toxin up-take and refolding, the intracellular actions of TcdB, and the treatment of C. difficile infection.
引用
收藏
页码：173 / 190
页数：18
相关论文
共 135 条
[1]   Clostridium difficile colitis: pathogenesis and host defence [J].
Abt, Michael C. ;
McKenney, Peter T. ;
Pamer, Eric G. .
NATURE REVIEWS MICROBIOLOGY, 2016, 14 (10) :609-620
[2]   Rho-modifying C3-like ADP-ribosyltransferases [J].
Aktories, K ;
Wilde, C ;
Vogelsgesang, M .
REVIEWS OF PHYSIOLOGY, BIOCHEMICAL AND PHARMACOLOGY, VOL 152, 2005, 152 :1-22
[3]   BOTULINUM ADP-RIBOSYLTRANSFERASE-C3 - A NEW TOOL TO STUDY LOW-MOLECULAR WEIGHT GTP-BINDING PROTEINS [J].
AKTORIES, K ;
HALL, A .
TRENDS IN PHARMACOLOGICAL SCIENCES, 1989, 10 (10) :415-418
[4]   CLOSTRIDIUM-BOTULINUM TYPE-C PRODUCES A NOVEL ADP-RIBOSYLTRANSFERASE DISTINCT FROM BOTULINUM-C2 TOXIN [J].
AKTORIES, K ;
WELLER, U ;
CHHATWAL, GS .
FEBS LETTERS, 1987, 212 (01) :109-113
[5]   THE RHO GENE-PRODUCT EXPRESSED IN ESCHERICHIA-COLI IS A SUBSTRATE OF BOTULINUM ADP-RIBOSYLTRANSFERASE-C3 [J].
AKTORIES, K ;
BRAUN, U ;
ROSENER, S ;
JUST, I ;
HALL, A .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 158 (01) :209-213
[6]   BOTULINUM-C2 TOXIN ADP-RIBOSYLATES ACTIN [J].
AKTORIES, K ;
BARMANN, M ;
OHISHI, I ;
TSUYAMA, S ;
JAKOBS, KH ;
HABERMANN, E .
NATURE, 1986, 322 (6077) :390-392
[7]   cAMP guided his way: a life for G protein-mediated signal transduction and molecular pharmacology-tribute to Karl H. Jakobs [J].
Aktories, Klaus ;
Gierschik, Peter ;
zu Heringdorf, Dagmar Meyer ;
Schmidt, Martina ;
Schultz, Guenter ;
Wieland, Thomas .
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2019, 392 (08) :887-911
[8]   Binary Clostridium difficile toxin (CDT) - A virulence factor disturbing the cytoskeleton [J].
Aktories, Klaus ;
Papatheodorou, Panagiotis ;
Schwan, Carsten .
ANAEROBE, 2018, 53 :21-29
[9]   Clostridium difficile Toxin Biology [J].
Aktories, Klaus ;
Schwan, Carsten ;
Jank, Thomas .
ANNUAL REVIEW OF MICROBIOLOGY, VOL 71, 2017, 71 :281-307
[10]  
Aktories K, 2017, HANDB EXP PHARMACOL, V235, P179, DOI 10.1007/164_2016_26
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