A BODIPY-based fluorescent probe for simultaneous detection of H2O2 and viscosity during the pyroptosis process

被引：11

作者：

Mei, Yuan ^{[1
]}

Li, Ziyun ^{[2
]}

Rong, Kuanrong ^{[2
]}

Hai, Zijuan ^{[3
,4
]}

Tang, Wenjian ^{[2
]}

Song, Qin-Hua ^{[1
]}

机构：

[1] Univ Sci & Technol China, Dept Chem, Hefei 230026, Peoples R China

[2] Anhui Med Univ, Sch Pharm, Hefei 230032, Peoples R China

[3] Anhui Univ, Inst Phys Sci, Key Lab Struct & Funct Regulat Hybrid Mat, Minist Educ, Hefei 230601, Anhui, Peoples R China

[4] Anhui Univ, Inst Informat Technol, Key Lab Struct & Funct Regulat Hybrid Mat, Minist Educ, Hefei 230601, Anhui, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2023年 / 59卷 / 85期

基金：

中国国家自然科学基金;

关键词：

HYDROGEN-PEROXIDE; MOLECULAR ROTORS; BLOOD-VISCOSITY; GASDERMIN D; INFLAMMASOME; CELLS;

D O I：

10.1039/d3cc03914e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A dual functional BODIPY fluorescent probe was developed for simultaneous detection of H2O2 and viscosity, by collecting fluorescence from 800-1100 nm and 550-750 nm, respectively. Bioimaging based on the probe shows that H2O2 accumulates and cytoplasmic viscosity increases during the palmitic acid (PA)-induced pyroptosis process.

引用

页码：12775 / 12778

页数：4

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