Total Neoadjuvant Treatment for Locally Advanced Rectal Cancer Patients: Where Do We Stand?

被引：15

作者：

Dapra, Valentina ^{[1
,2
]}

Airoldi, Marco ^{[1
,2
]}

Bartolini, Michela ^{[1
,2
]}

Fazio, Roberta ^{[1
,2
]}

Mondello, Giuseppe ^{[2
]}

Tronconi, Maria Chiara ^{[2
]}

Prete, Maria Giuseppina ^{[2
]}

D'Agostino, Giuseppe ^{[3
]}

Foppa, Caterina ^{[1
,4
]}

Spinelli, Antonino ^{[1
,4
]}

Puccini, Alberto ^{[2
]}

Santoro, Armando ^{[1
,2
]}

机构：

[1] Humanitas Univ, Dept Biomed Sci, I-20072 Pieve Emanuele, Italy

[2] IRCCS Humanitas Res Hosp, Humanitas Canc Ctr, Med Oncol & Hematol Unit, I-20089 Rozzano, Italy

[3] IRCCS Humanitas Res Hosp, Radiotherapy & Radiosurg Dept, I-20089 Rozzano, Italy

[4] IRCCS Humanitas Res Hosp, Div Colon & Rectal Surg, I-20089 Rozzano, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 15期

关键词：

locally advanced rectal cancer; total neoadjuvant therapy; rectal cancer; nonoperative management; ct-DNA; MMR-deficient tumor; TOTAL MESORECTAL EXCISION; SHORT-COURSE RADIOTHERAPY; METASTATIC COLORECTAL-CANCER; PHASE-III TRIAL; PREOPERATIVE RADIOTHERAPY; ADJUVANT CHEMOTHERAPY; RANDOMIZED-TRIAL; OPEN-LABEL; POSTOPERATIVE CHEMORADIOTHERAPY; FOLLOW-UP;

D O I：

10.3390/ijms241512159

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The therapeutic landscape in locally advanced rectal cancer (LARC) has undergone a significant paradigm shift in recent years with the rising adoption of total neoadjuvant treatment (TNT). This comprehensive approach entails administering chemotherapy and radiation therapy before surgery, followed by optional adjuvant chemotherapy. To establish and deliver the optimal tailored treatment regimen to the patient, it is crucial to foster collaboration among a multidisciplinary team comprising healthcare professionals from various specialties, including medical oncology, radiation oncology, surgical oncology, radiology, and pathology. This review aims to provide insights into the current state of TNT for LARC and new emerging strategies to identify potential directions for future research and clinical practice, such as circulating tumor-DNA, immunotherapy in mismatch-repair-deficient tumors, and nonoperative management.

引用

页数：16

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