KRAS G12C colon cancer resistance to vertical MAPK inhibition converges on FOS-JUN signaling through orthogonal mechanisms

被引:1
|
作者
Koleilat, Mohamad Karim
Kwong, Lawrence
机构
关键词
D O I
10.1158/1538-7445.AM2023-3893
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
3893
引用
收藏
页数:2
相关论文
共 50 条
  • [21] Scribble mis-localization induces adaptive resistance to KRAS G12C inhibitors through feedback activation of MAPK signaling mediated by YAP-induced MRAS
    Adachi, Yuta
    Kimura, Ryo
    Hirade, Kentaro
    Yanase, Shogo
    Nishioka, Yuki
    Kasuga, Natsumi
    Yamaguchi, Rui
    Ebi, Hiromichi
    NATURE CANCER, 2023, 4 (06) : 829 - +
  • [22] Scribble mis-localization induces adaptive resistance to KRAS G12C inhibitors through feedback activation of MAPK signaling mediated by YAP-induced MRAS
    Yuta Adachi
    Ryo Kimura
    Kentaro Hirade
    Shogo Yanase
    Yuki Nishioka
    Natsumi Kasuga
    Rui Yamaguchi
    Hiromichi Ebi
    Nature Cancer, 2023, 4 : 829 - 843
  • [23] KO-2806, a next-generation farnesyl transferase inhibitor, re-sensitizes KRAS G12C NSCLC tumors to KRAS G12C mutant-specific inhibitors through mTOR signaling inhibition
    Patel, H.
    Chan, S.
    Smith, A.
    Burrows, F.
    Malik, S.
    EUROPEAN JOURNAL OF CANCER, 2024, 211 : S146 - S146
  • [24] Vertical pathway inhibition with a SOS1::KRAS inhibitor enhances the efficacy of KRAS G12C inhibitors, delays feedback resistance and demonstrates durable response
    Savarese, F.
    Gmachl, M.
    Federico, L.
    Trapani, F.
    Gerlach, D.
    Daniele, J.
    Feng, N.
    Bristow, C. A.
    Machado, A.
    Huang, J.
    Rudolph, D.
    Waizenegger, I.
    Ramharter, J.
    Vellano, C. P.
    Petronczki, M.
    Marszalek, J. R.
    Heffernan, T. P.
    McConnell, D. B.
    Kraut, N.
    Hofmann, M.
    EUROPEAN JOURNAL OF CANCER, 2020, 138 : S22 - S22
  • [25] Aurora A kinase inhibition with VIC-1911 overcomes intrinsic and acquired resistance to KRASG12C inhibition in KRAS(G12C)-mutated lung cancer
    Lee, Jong Woo
    Kim, Sundong
    Yang, Cindy
    Burtness, Barbara
    MOLECULAR CANCER THERAPEUTICS, 2021, 20 (12)
  • [26] Efficacious Combination Drug Treatment for Colorectal Cancer That Overcomes Resistance to KRAS G12C Inhibitors
    Matsubara, Hiroyuki
    Miyoshi, Hiroyuki
    Kakizaki, Fumihiko
    Morimoto, Tomonori
    Kawada, Kenji
    Yamamoto, Takehito
    Obama, Kazutaka
    Sakai, Yoshiharu
    Taketo, Makoto Mark
    MOLECULAR CANCER THERAPEUTICS, 2023, 22 (04) : 529 - 538
  • [27] Progress of KRAS G12C inhibitors in the treatment of refractory colorectal cancer and strategies for drug resistance response
    Yang, Peiyuan
    Li, Yongchao
    INVESTIGATIONAL NEW DRUGS, 2025,
  • [28] Concomitant KRAS mutations attenuate sensitivity of non-small cell lung cancer cells to KRAS G12C inhibition
    Tereza Vaclova
    Atanu Chakraborty
    James Sherwood
    Sarah Ross
    Danielle Carroll
    J. Carl Barrett
    Julian Downward
    Elza C. de Bruin
    Scientific Reports, 12
  • [29] Concomitant KRAS mutations attenuate sensitivity of non-small cell lung cancer cells to KRAS G12C inhibition
    Vaclova, Tereza
    Chakraborty, Atanu
    Sherwood, James
    Ross, Sarah
    Carroll, Danielle
    Barrett, J. Carl
    Downward, Julian
    de Bruin, Elza C.
    SCIENTIFIC REPORTS, 2022, 12 (01)
  • [30] Suppression of mutant Kirsten-RAS (KRAS G12C) non-small cell lung cancer (NSCLC) resistance to KRAS G12C inhibitors by dual inhibition of hepatocyte growth factor receptor (MET) and V-ATPase
    Rosell, R.
    Gomez-Vazquez, J. L.
    Lewintre, E. Jantus
    Ito, M.
    Cao, P.
    Cai, X.
    Xing, B.
    Farinas, S. Calabuig
    Cardona, A. F.
    Rodriguez, J. K.
    Jordan, M. Marco
    Valdunciel, C. Pedraz
    Molina-Vila, M. A.
    Codony-Servat, J.
    Dantes, Z.
    Aguilar, A.
    Sullivan, I. G.
    Horno, I. Moya
    Cirera, L.
    Gonzalez-Cao, M.
    JOURNAL OF THORACIC ONCOLOGY, 2023, 18 (04) : S149 - S149