Dynamic Hydrogen-Bonded Zinc Adeninate Framework (ZAF) for Immobilization of Catalytic DNA

被引：5

作者：

Baslyman, Walaa S. ^{[1
]}

Alahmed, Othman ^{[1
,2
]}

Chand, Santanu ^{[1
,3
]}

Qutub, Somayah ^{[1
]}

Khashab, Niveen M. ^{[1
]}

机构：

[1] King Abdullah Univ Sci & Technol KAUST, Adv Membranes & Porous Mat Ctr, Phys Sci & Engn Div, Smart Hybrid Mat SHMs Lab, Thuwal 239556900, Saudi Arabia

[2] King Saud Bin Abdulaziz Univ Hlth Sci, King Abdullah Int Med Res Ctr, Dev Med Dept, Minist Natl Guard Hlth Affairs MNG HA, Riyadh 11481, Saudi Arabia

[3] Univ Tokyo, Grad Sch Engn, Dept Appl Chem, Bunkyo Ku, Tokyo 1138656, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2023年 / 62卷 / 25期

关键词：

Gene Delivery; Hydrogen-Bonded Organic Frameworks; Immobilization; Self-Assembly; Zeolitic Framework; METAL-ORGANIC FRAMEWORKS; DELIVERY;

D O I：

10.1002/anie.202302840

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Effective immobilization and delivery of genetic materials is at the forefront of biological and medical research directed toward tackling scientific challenges such as gene therapy and cancer treatment. Herein we present a biologically inspired hydrogen-bonded zinc adeninate framework (ZAF) consisting of zinc adeninate macrocycles that self-assemble into a 3D framework through adenine-adenine interactions. ZAF can efficiently immobilize DNAzyme with full protection against enzyme degradation and physiological conditions until it is successfully delivered into the nucleus. As compared to zeolitic imidazolate frameworks (ZIFs), ZAFs are twofold more biocompatible with a significant loading efficiency of 96 %. Overall, our design paves the way for expanding functional hydrogen-bonding-based systems as potential platforms for the loading and delivery of biologics.

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页数：7

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