Regulating Androgen Receptor Function in Prostate Cancer: Exploring the Diversity of Post-Translational Modifications

被引：3
|
作者：
Lumahan, Lance Edward V. [1 ]
Arif, Mazia [2 ]
Whitener, Amy E. [2 ]
Yi, Ping [2 ]
机构：
[1] Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77204 USA
[2] Univ Houston, Ctr Nucl Receptors & Cell Signaling, Dept Biol & Biochem, Houston, TX 77205 USA
来源：
CELLS | 2024年 / 13卷 / 02期
关键词：
androgen receptor; post-translational modifications; prostate cancer; acetylation; methylation; phosphorylation; ubiquitination; sumoylation; DEUBIQUITINATING ENZYME USP12; TRANSCRIPTIONAL ACTIVITY; GLUCOCORTICOID-RECEPTOR; DEPENDENT TRANSCRIPTION; COVALENT MODIFICATION; CELL-PROLIFERATION; RESPONSE ELEMENT; BINDING PROTEIN; LIGAND-BINDING; FEEDBACK LOOP;
D O I：
10.3390/cells13020191
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Androgen receptor (AR) transcriptional activity significantly influences prostate cancer (PCa) progression. In addition to ligand stimulation, AR transcriptional activity is also influenced by a variety of post-translational modifications (PTMs). A number of oncogenes and tumor suppressors have been observed leveraging PTMs to influence AR activity. Subjectively targeting these post-translational modifiers based on their impact on PCa cell proliferation is a rapidly developing area of research. This review elucidates the modifiers, contextualizes the effects of these PTMs on AR activity, and connects these cellular interactions to the progression of PCa.
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页数：22
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