Regulating Androgen Receptor Function in Prostate Cancer: Exploring the Diversity of Post-Translational Modifications

被引：3
|
作者：
Lumahan, Lance Edward V. [1 ]
Arif, Mazia [2 ]
Whitener, Amy E. [2 ]
Yi, Ping [2 ]
机构：
[1] Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77204 USA
[2] Univ Houston, Ctr Nucl Receptors & Cell Signaling, Dept Biol & Biochem, Houston, TX 77205 USA
来源：
CELLS | 2024年 / 13卷 / 02期
关键词：
androgen receptor; post-translational modifications; prostate cancer; acetylation; methylation; phosphorylation; ubiquitination; sumoylation; DEUBIQUITINATING ENZYME USP12; TRANSCRIPTIONAL ACTIVITY; GLUCOCORTICOID-RECEPTOR; DEPENDENT TRANSCRIPTION; COVALENT MODIFICATION; CELL-PROLIFERATION; RESPONSE ELEMENT; BINDING PROTEIN; LIGAND-BINDING; FEEDBACK LOOP;
D O I：
10.3390/cells13020191
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Androgen receptor (AR) transcriptional activity significantly influences prostate cancer (PCa) progression. In addition to ligand stimulation, AR transcriptional activity is also influenced by a variety of post-translational modifications (PTMs). A number of oncogenes and tumor suppressors have been observed leveraging PTMs to influence AR activity. Subjectively targeting these post-translational modifiers based on their impact on PCa cell proliferation is a rapidly developing area of research. This review elucidates the modifiers, contextualizes the effects of these PTMs on AR activity, and connects these cellular interactions to the progression of PCa.
引用
收藏
页数：22
相关论文
共 50 条
  • [1] Post-Translational Modifications That Drive Prostate Cancer Progression
    Samarzija, Ivana
    BIOMOLECULES, 2021, 11 (02) : 1 - 44
  • [2] Androgen receptor post-translational modifications and their implications for pathology
    Montoya-Novoa, Ines
    Gardeazabal-Torbado, Jose Luis
    Alegre-Marti, Andrea
    Fuentes-Prior, Pablo
    Estebanez-Perpina, Eva
    BIOCHEMICAL SOCIETY TRANSACTIONS, 2024, 52 (04) : 1673 - 1694
  • [3] Regulation of the androgen receptor by post-translational modifications
    Coffey, Kelly
    Robson, Craig N.
    JOURNAL OF ENDOCRINOLOGY, 2012, 215 (02) : 221 - 237
  • [4] Post-translational modifications in neurodegeneration
    Didonna, Alessandro
    Benetti, Federico
    AIMS BIOPHYSICS, 2016, 3 (01): : 27 - 49
  • [5] Posttranslational regulation of androgen dependent and independent androgen receptor activities in prostate cancer
    Wen, Simeng
    Niu, Yuanjie
    Huang, Haojie
    ASIAN JOURNAL OF UROLOGY, 2020, 7 (03) : 203 - 218
  • [6] Post-translational modifications of the mineralocorticoid receptor: How to dress the receptor according to the circumstances?
    Faresse, Nourdine
    JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2014, 143 : 334 - 342
  • [7] Post-translational modifications on the retinoblastoma protein
    Zhou, Linbin
    Ng, Danny Siu-Chun
    Yam, Jason C.
    Chen, Li Jia
    Tham, Clement C.
    Pang, Chi Pui
    Chu, Wai Kit
    JOURNAL OF BIOMEDICAL SCIENCE, 2022, 29 (01)
  • [8] The role of protein post-translational modifications in prostate cancer
    Hao, Yinghui
    Gu, Chenqiong
    Luo, Wenfeng
    Shen, Jian
    Xie, Fangmei
    Zhao, Ying
    Song, Xiaoyu
    Han, Zeping
    He, Jinhua
    PEERJ, 2024, 12
  • [9] Post-translational modifications in diabetic cardiomyopathy
    Li, Zhi
    Chen, Jie
    Huang, Hailong
    Zhan, Qianru
    Wang, Fengzhi
    Chen, Zihan
    Lu, Xinwei
    Sun, Guozhe
    JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2024, 28 (07)
  • [10] The Role of Hypoxia-Inducible Factor Post-Translational Modifications in Regulating Its Localisation, Stability, and Activity
    Albanese, Adam
    Daly, Leonard A.
    Mennerich, Daniela
    Kietzmann, Thomas
    See, Violaine
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (01) : 1 - 18
12345