A Distinctive Insight into Inorganic Sonosensitizers: Design Principles and Application Domains

被引：35

作者：

Qin, Wen ^{[1
,2
,3
]}

Yang, Qiaoling ^{[1
,2
,3
]}

Zhu, Chunyan ^{[2
,3
,4
]}

Jiao, Rong ^{[1
,2
,3
]}

Lin, Xia ^{[1
,2
,3
]}

Fang, Chao ^{[2
,3
,4
]}

Guo, Jiaming ^{[5
]}

Zhang, Kun ^{[2
,3
]}

机构：

[1] Guangxi Med Univ, Collaborat Innovat Ctr Targeting Tumor Diag & The, Natl Ctr Int Res Biotargeting Theranost, State Key Lab Targeting Oncol,Guangxi Key Lab Biot, Nanning 530021, Guangxi, Peoples R China

[2] Univ Elect Sci & Technol China, Sichuan Acad Med Sci, Sichuan Prov Peoples Hosp, Dept Pharm,Sch Med, 32 West Second Sect,First Ring Rd, Chengdu 610072, Sichuan, Peoples R China

[3] Univ Elect Sci & Technol China, Sichuan Acad Med Sci, Sichuan Prov Peoples Hosp, Dept Med Ultrasound,Sch Med, 32 West Second Sect,First Ring Rd, Chengdu 610072, Sichuan, Peoples R China

[4] Tongji Univ, Shanghai Peoples Hosp 10, Dept Med Ultrasound, Sch Med, 301 Yanchangzhong Rd, Shanghai 200072, Peoples R China

[5] Naval Med Univ, Coll Naval Med, Dept Radiat Med, 800 Xiangyin Rd, Shanghai 200433, Peoples R China

来源：

SMALL | 2024年 / 20卷 / 25期

基金：

中国国家自然科学基金;

关键词：

combined therapy; design principles; inorganic sonosensitizers; non-cancer treatment; tumor microenvironment regulation; SONODYNAMIC THERAPY; TUMOR STARVATION; NANOPARTICLES; ULTRASOUND; NANOSHEETS; TITANIUM; NANOSONOSENSITIZERS; POLYPYRROLE; METABOLISM;

D O I：

10.1002/smll.202311228

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Sonodynamic therapy (SDT) as a promising non-invasive anti-tumor means features the preferable penetration depth, which nevertheless, usually can't work without sonosensitizers. Sonosensitizers produce reactive oxygen species (ROS) in the presence of ultrasound to directly kill tumor cells, and concurrently activate anti-tumor immunity especially after integration with tumor microenvironment (TME)-engineered nanobiotechnologies and combined therapy. Current sonosensitizers are classified into organic and inorganic ones, and current most reviews only cover organic sonosensitizers and highlighted their anti-tumor applications. However, there have few specific reviews that focus on inorganic sonosensitizers including their design principles, microenvironment regulation, etc. In this review, inorganic sonosensitizers are first classified according to their design rationales rather than composition, and the action rationales and underlying chemistry features are highlighted. Afterward, what and how TME is regulated based on the inorganic sonosensitizers-based SDT nanoplatform with an emphasis on the TME targets-engineered nanobiotechnologies are elucidated. Additionally, the combined therapy and their applications in non-cancer diseases are also outlined. Finally, the setbacks and challenges, and proposed the potential solutions and future directions is pointed out. This review provides a comprehensive and detailed horizon on inorganic sonosensitizers, and will arouse more attentions on SDT. Inorganic sonosensitizers according to their design rationales rather than composition, and highlighted the action rationales and underlying chemistry features are summarized, wherein design principles are highlighted, followed by elucidations on tumor microenvironment-engineered inorganic sonosensitizers and combined therapy, for cancer and non-cancer applications.image

引用

页数：29

共 212 条

[81] Electroactive Biomaterials and Systems for Cell Fate Determination and Tissue Regeneration: Design and Applications [J].