Advances in Drug Discovery Targeting Lysosomal Membrane Proteins

被引:6
|
作者
Wang, Hongna [1 ,2 ]
Zhu, Yidong [1 ,2 ]
Liu, Huiyan [1 ,2 ]
Liang, Tianxiang [1 ,2 ]
Wei, Yongjie [1 ,2 ,3 ]
机构
[1] Inst Guangzhou Med Univ, Affiliated Canc Hosp, Guangzhou 510095, Peoples R China
[2] Canc Res Guangdong Higher Educ Inst, Key Lab Cell Homeostasis, Guangzhou 510095, Peoples R China
[3] Guangzhou Inst Resp Hlth, Natl Clin Res Ctr Resp Dis, State Key Lab Resp Dis, Guangzhou 510095, Peoples R China
基金
中国国家自然科学基金;
关键词
lysosome; drug; lysosomal membrane protein; therapy; disease; target; NIEMANN-PICK C1; INTEGRAL MEMBRANE; BONE-RESORPTION; ION CHANNELS; PROTON PUMP; V-ATPASES; INHIBITORS; AUTOPHAGY; REQUIRES; TMEM175;
D O I
10.3390/ph16040601
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Lysosomes are essential organelles of eukaryotic cells and are responsible for various cellular functions, including endocytic degradation, extracellular secretion, and signal transduction. There are dozens of proteins localized to the lysosomal membrane that control the transport of ions and substances across the membrane and are integral to lysosomal function. Mutations or aberrant expression of these proteins trigger a variety of disorders, making them attractive targets for drug development for lysosomal disorder-related diseases. However, breakthroughs in R&D still await a deeper understanding of the underlying mechanisms and processes of how abnormalities in these membrane proteins induce related diseases. In this article, we summarize the current progress, challenges, and prospects for developing therapeutics targeting lysosomal membrane proteins for the treatment of lysosomal-associated diseases.
引用
收藏
页数:21
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