Copper-Catalyzed Tandem Cyclization/Direct C(sp2)-H Annulation of Azide-Ynamides via ?-Imino Copper Carbenes: Access to Azepino[2,3-b:4,5-b?]diindoles

被引：8

作者：

Chen, Yi ^{[1
]}

Yan, Yao-Hong ^{[1
]}

Zhu, Bo-Han ^{[1
]}

Chen, Fan ^{[1
]}

Li, Long ^{[1
]}

Qian, Peng-Cheng ^{[1
,2
]}

机构：

[1] Wenzhou Univ, Coll Chem & Mat Engn, Wenzhou 325035, Peoples R China

[2] Wenzhou Univ, Inst New Mat & Ind Technol, Wenzhou Key Lab Technol & Applicat Environm Funct, Wenzhou 325000, Peoples R China

来源：

ORGANIC LETTERS | 2023年 / 25卷 / 12期

基金：

中国国家自然科学基金;

关键词：

INTERMOLECULAR REACTION; 2-ALKYNYL ARYLAZIDES; CASCADE CYCLIZATION; RAPID ACCESS; GOLD; INDOLES; DIYNES; REGIOSELECTIVITY; CYCLOADDITION; CONSTRUCTION;

D O I：

10.1021/acs.orglett.3c00434

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel copper-catalyzed tandem cyclization/direct C(sp2)-H annulation of phenyl azide-ynamides via alpha-imino copper carbenes has been developed, which provides a concise and flexible approach for the construction of a range of valuable azepino[2,3-b:4,5b ']diindoles in mostly good to excellent yields with high chemoselectivities. This tandem reaction also exhibits a broad substrate scope, excellent functional group tolerance, simple operation, and mild reaction conditions.

引用

页码：2063 / 2067

页数：5

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