This study is the first chemical investigation of Ferula mervynii M. Sagiroglu & H. Duman, an endemic species to Eastern Anatolia. The isolations of nine compounds including six previously undescribed sesquiterpene esters, 8-trans-cinnamoyltovarol (1), 8-trans-cinnamoylantakyatriol (3), 6-acetyl-8-trans-cinnamoyl-3-epi-antakyatriol (5), 6-acetyl-8-trans-cinnamoylshiromodiol (6), 6-acetyl-8-trans-cinnamoylfermedurone (7), and 6-acetyl-8-trans-cinnamoyl-(1S),2-epoxyfermedurone (8), were described along with three known sesquiterpene esters, 6-acetyl-8-benzoyltovarol (2), 6-acetyl-8-trans-cinnamoylantakyatriol (4), and ferutinin (9). The structures of novel compounds were elucidated through extensive spectroscopic analyses and quantum chemistry calculations. The putative biosynthetic pathways for compounds 7 and 8 were discussed. The extracts and isolated compounds were tested for cytotoxic activity against the COLO 205, K-562, MCF-7 cancer cell lines, and Human Umbilical Vein Endothelial Cell (HUVEC) lines using MTT assay. Compound 4 showed the highest activity against the MCF-7 cell lines with an IC50 value of 16.74 +/- 0.21 mu M.
机构:
Fudan Univ, Sch Pharm, Shanghai 201203, Peoples R ChinaFudan Univ, Sch Pharm, Shanghai 201203, Peoples R China
Liu, Tao
Osman, Khadijo
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UCL Sch Pharm, Dept Pharmaceut & Biol Chem, London, EnglandFudan Univ, Sch Pharm, Shanghai 201203, Peoples R China
Osman, Khadijo
Kaatz, Glenn W.
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Wayne State Univ, Sch Med, John D Dingell Dept Vet Affairs Med Ctr, Detroit, MI USA
Wayne State Univ, Sch Med, Dept Internal Med, Div Infect Dis, Detroit, MI 48201 USAFudan Univ, Sch Pharm, Shanghai 201203, Peoples R China
Kaatz, Glenn W.
Gibbons, Simon
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UCL Sch Pharm, Dept Pharmaceut & Biol Chem, London, EnglandFudan Univ, Sch Pharm, Shanghai 201203, Peoples R China
Gibbons, Simon
Mu, Qing
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Fudan Univ, Sch Pharm, Shanghai 201203, Peoples R ChinaFudan Univ, Sch Pharm, Shanghai 201203, Peoples R China
机构:
Chinese Acad Med Sci & Peking Union Med Coll, Inst Med Plant Dev, Minist Educ, Key Lab Bioact Subst & Resources Utilizat Chinese, 151 Malianwa North Rd, Beijing 100193, Peoples R ChinaChinese Acad Med Sci & Peking Union Med Coll, Inst Med Plant Dev, Minist Educ, Key Lab Bioact Subst & Resources Utilizat Chinese, 151 Malianwa North Rd, Beijing 100193, Peoples R China
Wang, Junchi
Yan, Haoli
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Ctr Food & Drug Evaluat & Inspect Henan, Zhengzhou, Peoples R ChinaChinese Acad Med Sci & Peking Union Med Coll, Inst Med Plant Dev, Minist Educ, Key Lab Bioact Subst & Resources Utilizat Chinese, 151 Malianwa North Rd, Beijing 100193, Peoples R China
Yan, Haoli
Huo, Xiaoshuang
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Chinese Acad Med Sci & Peking Union Med Coll, Inst Med Plant Dev, Minist Educ, Key Lab Bioact Subst & Resources Utilizat Chinese, 151 Malianwa North Rd, Beijing 100193, Peoples R ChinaChinese Acad Med Sci & Peking Union Med Coll, Inst Med Plant Dev, Minist Educ, Key Lab Bioact Subst & Resources Utilizat Chinese, 151 Malianwa North Rd, Beijing 100193, Peoples R China
Huo, Xiaoshuang
Li, Lingyu
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Chinese Acad Med Sci & Peking Union Med Coll, Inst Med Plant Dev, Minist Educ, Key Lab Bioact Subst & Resources Utilizat Chinese, 151 Malianwa North Rd, Beijing 100193, Peoples R ChinaChinese Acad Med Sci & Peking Union Med Coll, Inst Med Plant Dev, Minist Educ, Key Lab Bioact Subst & Resources Utilizat Chinese, 151 Malianwa North Rd, Beijing 100193, Peoples R China
Li, Lingyu
Wang, Huijuan
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Chinese Acad Med Sci & Peking Union Med Coll, Inst Med Plant Dev, Minist Educ, Key Lab Bioact Subst & Resources Utilizat Chinese, 151 Malianwa North Rd, Beijing 100193, Peoples R ChinaChinese Acad Med Sci & Peking Union Med Coll, Inst Med Plant Dev, Minist Educ, Key Lab Bioact Subst & Resources Utilizat Chinese, 151 Malianwa North Rd, Beijing 100193, Peoples R China
Wang, Huijuan
Zhang, Meng
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Chinese Acad Med Sci & Peking Union Med Coll, Inst Med Plant Dev, Minist Educ, Key Lab Bioact Subst & Resources Utilizat Chinese, 151 Malianwa North Rd, Beijing 100193, Peoples R ChinaChinese Acad Med Sci & Peking Union Med Coll, Inst Med Plant Dev, Minist Educ, Key Lab Bioact Subst & Resources Utilizat Chinese, 151 Malianwa North Rd, Beijing 100193, Peoples R China
Zhang, Meng
Li, Xiaojin
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Xinjiang Inst Chinese Mat Med & Eth Mat Med, Urumqi, Peoples R ChinaChinese Acad Med Sci & Peking Union Med Coll, Inst Med Plant Dev, Minist Educ, Key Lab Bioact Subst & Resources Utilizat Chinese, 151 Malianwa North Rd, Beijing 100193, Peoples R China
Li, Xiaojin
Zhao, Yaqin
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Xinjiang Inst Chinese Mat Med & Eth Mat Med, Urumqi, Peoples R ChinaChinese Acad Med Sci & Peking Union Med Coll, Inst Med Plant Dev, Minist Educ, Key Lab Bioact Subst & Resources Utilizat Chinese, 151 Malianwa North Rd, Beijing 100193, Peoples R China
Zhao, Yaqin
Chen, Gang
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Xinjiang Inst Chinese Mat Med & Eth Mat Med, Urumqi, Peoples R ChinaChinese Acad Med Sci & Peking Union Med Coll, Inst Med Plant Dev, Minist Educ, Key Lab Bioact Subst & Resources Utilizat Chinese, 151 Malianwa North Rd, Beijing 100193, Peoples R China
Chen, Gang
Si, Jianyong
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Chinese Acad Med Sci & Peking Union Med Coll, Inst Med Plant Dev, Minist Educ, Key Lab Bioact Subst & Resources Utilizat Chinese, 151 Malianwa North Rd, Beijing 100193, Peoples R ChinaChinese Acad Med Sci & Peking Union Med Coll, Inst Med Plant Dev, Minist Educ, Key Lab Bioact Subst & Resources Utilizat Chinese, 151 Malianwa North Rd, Beijing 100193, Peoples R China