Novel Cytotoxic Sesquiterpene Ester Derivatives from the Roots of Ferula mervynii

被引:2
|
作者
Yazici Bektas, Nurdan [1 ,2 ]
Altiparmak Ulbegi, Gulsum [3 ]
Aksoy Sagirli, Pinar [3 ]
Miski, Mahmut [1 ]
机构
[1] Istanbul Univ, Fac Pharm, Dept Pharmacognosy, TR-34116 Istanbul, Turkiye
[2] Karadeniz Tech Univ, Fac Pharm, Dept Pharmacognosy, Trabzon, Turkiye
[3] Istanbul Univ, Fac Pharm, Dept Biochem, Istanbul, Turkiye
关键词
Apiaceae; cytotoxicity; Ferula mervynii; nor-ketoelemane type sesquiterpene; putative biosynthetic pathway; quantum chemistry calculation; sesquiterpene; ANTITUMOR-ACTIVITY; DAUCANE ESTERS; ARYL ESTERS; ANTIOXIDANT; COMMUNIS; APIACEAE; CELLS; RESIN;
D O I
10.1002/cbdv.202201058
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
This study is the first chemical investigation of Ferula mervynii M. Sagiroglu & H. Duman, an endemic species to Eastern Anatolia. The isolations of nine compounds including six previously undescribed sesquiterpene esters, 8-trans-cinnamoyltovarol (1), 8-trans-cinnamoylantakyatriol (3), 6-acetyl-8-trans-cinnamoyl-3-epi-antakyatriol (5), 6-acetyl-8-trans-cinnamoylshiromodiol (6), 6-acetyl-8-trans-cinnamoylfermedurone (7), and 6-acetyl-8-trans-cinnamoyl-(1S),2-epoxyfermedurone (8), were described along with three known sesquiterpene esters, 6-acetyl-8-benzoyltovarol (2), 6-acetyl-8-trans-cinnamoylantakyatriol (4), and ferutinin (9). The structures of novel compounds were elucidated through extensive spectroscopic analyses and quantum chemistry calculations. The putative biosynthetic pathways for compounds 7 and 8 were discussed. The extracts and isolated compounds were tested for cytotoxic activity against the COLO 205, K-562, MCF-7 cancer cell lines, and Human Umbilical Vein Endothelial Cell (HUVEC) lines using MTT assay. Compound 4 showed the highest activity against the MCF-7 cell lines with an IC50 value of 16.74 +/- 0.21 mu M.
引用
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页数:12
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