Whole-brain structure-function coupling abnormalities in mild cognitive impairment: a study combining amplitude of low-frequency fluctuations and voxel-based morphometry

被引:2
作者
Zhao, Rong [1 ]
Wang, Pan [1 ]
Liu, Lin [1 ]
Zhang, Fanyu [1 ]
Hu, Peng [1 ]
Wen, Jiaping [1 ]
Li, Hongyi [2 ]
Biswal, Bharat B. [1 ,3 ]
机构
[1] Univ Elect Sci & Technol China, Clin Hosp, Chengdu Brain Sci Inst, Ctr Informat Med,Sch Life Sci Technol,MOE Key Lab, Chengdu, Peoples R China
[2] Fourth Peoples Hosp Chengdu, Chengdu, Peoples R China
[3] New Jersey Inst Technol, Dept Biomed Engn, Newark, NJ 07102 USA
基金
中国国家自然科学基金;
关键词
Alzheimer's disease; amplitude of low frequency fluctuations; structure-function coupling; voxel-based morphometry; white matter; ALZHEIMERS-DISEASE; WHITE-MATTER; EXECUTIVE FUNCTION; PARAHIPPOCAMPAL GYRUS; ORBITOFRONTAL CORTEX; CORPUS-CALLOSUM; CONNECTIVITY; STATE; NETWORKS; DEMENTIA;
D O I
10.3389/fnins.2023.1236221
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Alzheimer's disease (AD), one of the leading diseases of the nervous system, is accompanied by symptoms such as loss of memory, thinking and language skills. Both mild cognitive impairment (MCI) and very mild cognitive impairment (VMCI) are the transitional pathological stages between normal aging and AD. While the changes in whole-brain structural and functional information have been extensively investigated in AD, The impaired structure-function coupling remains unknown. The current study employed the OASIS-3 dataset, which includes 53 MCI, 90 VMCI, and 100 Age-, gender-, and education-matched normal controls (NC). Several structural and functional parameters, such as the amplitude of low-frequency fluctuations (ALFF), voxel-based morphometry (VBM), and The ALFF/VBM ratio, were used To estimate The whole-brain neuroimaging changes In MCI, VMCI, and NC. As disease symptoms became more severe, these regions, distributed in the frontal-inf-orb, putamen, and paracentral lobule in the white matter (WM), exhibited progressively increasing ALFF (ALFF(NC) < ALFF(VMCI) < ALFF(MCI)), which was similar to the tendency for The cerebellum and putamen in the gray matter (GM). Additionally, as symptoms worsened in AD, the cuneus/frontal lobe in the WM and the parahippocampal gyrus/hippocampus in the GM showed progressively decreasing structure-function coupling. As the typical focal areas in AD, The parahippocampal gyrus and hippocampus showed significant positive correlations with the severity of cognitive impairment, suggesting the important applications of the ALFF/VBM ratio in brain disorders. On the other hand, these findings from WM functional signals provided a novel perspective for understanding the pathophysiological mechanisms involved In cognitive decline in AD.
引用
收藏
页数:12
相关论文
共 83 条
  • [1] Abramian D., 2020, 2020 IEEE 17 INT S B, V237
  • [2] Diffusion-informed spatial smoothing of fMRI data in white matter using spectral graph filters
    Abramian, David
    Larsson, Martin
    Eklund, Anders
    Aganj, Iman
    Westin, Carl-Fredrik
    Behjat, Hamid
    [J]. NEUROIMAGE, 2021, 237
  • [3] Perfusion abnormalities in mild cognitive impairment and mild dementia in Alzheimer's disease measured by pulsed arterial spin labeling MRI
    Alexopoulos, Panagiotis
    Sorg, Christian
    Foerschler, Annette
    Grimmer, Timo
    Skokou, Maria
    Wohlschlaeger, Afra
    Perneczky, Robert
    Zimmer, Claus
    Kurz, Alexander
    Preibisch, Christine
    [J]. EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE, 2012, 262 (01) : 69 - 77
  • [4] Abnormal whole-brain functional connection in amnestic mild cognitive impairment patients
    Bai, Feng
    Liao, Wei
    Watson, David R.
    Shi, Yongmei
    Wang, Yi
    Yue, Chunxian
    Teng, Yuhuan
    Wu, Di
    Yuan, Yonggui
    Jia, Jianping
    Zhang, Zhijun
    [J]. BEHAVIOURAL BRAIN RESEARCH, 2011, 216 (02) : 666 - 672
  • [5] Diffusion Tensor Imaging Revealed Microstructural Changes in Normal-Appearing White Matter Regions in Relapsing-Remitting Multiple Sclerosis
    Bao, Jianfeng
    Tu, Hui
    Li, Yijia
    Sun, Jubao
    Hu, Zhigang
    Zhang, Fengshou
    Li, Jinghua
    [J]. FRONTIERS IN NEUROSCIENCE, 2022, 16
  • [6] Flow of information for emotions through temporal and orbitofrontal pathways
    Barbas, Helen
    [J]. JOURNAL OF ANATOMY, 2007, 211 (02) : 237 - 249
  • [7] Focal basal ganglia lesions are associated with impairments in reward-based reversal learning
    Bellebaum, Christian
    Koch, Benno
    Schwarz, Michael
    Daum, Irene
    [J]. BRAIN, 2008, 131 : 829 - 841
  • [8] A New Insight on the Role of the Cerebellum for Executive Functions and Emotion Processing in Adults
    Beuriat, Pierre-Aurelien
    Cohen-Zimerman, Shira
    Smith, Gretchen N. L.
    Krueger, Frank
    Gordon, Barry
    Grafman, Jordan
    [J]. FRONTIERS IN NEUROLOGY, 2020, 11
  • [9] FUNCTIONAL CONNECTIVITY IN THE MOTOR CORTEX OF RESTING HUMAN BRAIN USING ECHO-PLANAR MRI
    BISWAL, B
    YETKIN, FZ
    HAUGHTON, VM
    HYDE, JS
    [J]. MAGNETIC RESONANCE IN MEDICINE, 1995, 34 (04) : 537 - 541
  • [10] A WHITE MATTER DISORDER IN DEMENTIA OF THE ALZHEIMER TYPE - A PATHOANATOMICAL STUDY
    BRUN, A
    ENGLUND, E
    [J]. ANNALS OF NEUROLOGY, 1986, 19 (03) : 253 - 262