Rodent-adapted Cryptosporidium infection in humans: Seven new cases and review of the literature

被引:8
作者
Stensvold, Christen Rune [1 ,8 ]
Larsen, Tine Graakjaer [2 ,3 ]
Gruttner, Jana [1 ,3 ]
Nielsen, Lene [4 ,5 ]
Engberg, Jurgen [6 ]
Lebbad, Marianne [7 ,9 ]
机构
[1] Statens Serum Inst, Dept Bacteria Parasites & Fungi, Lab Parasitol, Copenhagen, Denmark
[2] Statens Serum Inst, Dept Infect Dis Epidemiol & Prevent, Copenhagen, Denmark
[3] European Ctr Dis Prevent & Control ECDC, European Programme Publ Hlth Microbiol Training EU, Stockholm, Sweden
[4] Copenhagen Univ Hosp, Dept Clin Microbiol, Herlev, Denmark
[5] Copenhagen Univ Hosp, Gentofte, Denmark
[6] Zealand Univ Hosp, Dept Clin Microbiol, Roskilde, Denmark
[7] Sjobjornsvagen, Stockholm, Sweden
[8] Statens Serum Inst, Dept Bacteria Parasites & Fungi, Lab Parasitol, Artillerivej 5, DK-2300 Copenhagen S, Denmark
[9] Publ Hlth Agcy Sweden, Dept Microbiol, Solna, Sweden
关键词
Protozoa; Zoonosis; Surveillance; One Health; Molecular methods; Parasites; Rodents; SP APICOMPLEXA CRYPTOSPORIDIIDAE; MOLECULAR CHARACTERIZATION; GENETIC DIVERSITY; VIATORUM; SPP; IDENTIFICATION; TRANSMISSION; TYZZERI; PARVUM; N;
D O I
10.1016/j.onehlt.2024.100682
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Cases of cryptosporidiosis in humans have been reported with strong indication of transmission from rodents. Here, we report seven new human cases of cryptosporidiosis involving rodent-adapted species (Cryptosporidium ditrichi [n = 1], Cryptosporidium mortiferum [n = 4; previously known as Cryptosporidium chipmunk genotype I], Cryptosporidium tyzzeri [n = 1], and Cryptosporidium viatorum [n = 1]) and review cases of human infection caused by these four species published to date. The seven new cases were detected in Denmark within a period of twelve months from 2022 to 2023. Only the C. tyzzeri and C. viatorum cases were associated with travel outside Denmark. The total number of human cases of cryptosporidiosis due to C. ditrichi and C. tyzzeri documented to date globally are still limited (4 and 7, respectively), whereas cases involving C. viatorum and C. mortiferum have been detected to a larger extent (43 and 63 cases, respectively). The four new cases of C. mortiferum were all of the XIVaA20G2T1 subtype, which is the only subtype identified so far in Scandinavia, and which is a subtype not yet found outside of Scandinavia. The new C. viatorum case was identified as the XVaA3g subtype. The C. tyzzeri case was subtyped as IXbA6. No subtype data were produced for C. ditrichi due to lack of a subtype assay. Review of existing data suggests the presence of C. ditrichi and C. mortiferum primarily in northern countries and C. tyzzeri and C. viatorum primarily in warmer climates. While our data may further support the role of Cryptosporidium as a cause of zoonotic disease, case descriptions should be obtained where possible to determine if Cryptosporidium species primarily adapted to rodents are the likely cause of symptoms or just an incidental finding.
引用
收藏
页数:10
相关论文
共 60 条
[41]   Native and introduced squirrels in Italy host different Cryptosporidium spp. [J].
Prediger, Jitka ;
Horcickova, Michaela ;
Hofmannova, Lada ;
Sak, Bohumil ;
Ferrari, Nicola ;
Mazzamuto, Maria Vittoria ;
Romeo, Claudia ;
Wauters, Lucas A. ;
McEvoy, John ;
Kvac, Martin .
EUROPEAN JOURNAL OF PROTISTOLOGY, 2017, 61 :64-75
[42]   Human Cryptosporidiosis Caused by Cryptosporidium tyzzeri and C. parvum Isolates Presumably Transmitted from Wild Mice [J].
Raskova, Veronika ;
Kvetonova, Dana ;
Sak, Bohumil ;
McEvoy, John ;
Edwinson, Adam ;
Stenger, Brianna ;
Kvac, Martin .
JOURNAL OF CLINICAL MICROBIOLOGY, 2013, 51 (01) :360-362
[43]   Cryptosporidium tyzzeri n. sp (Apicomplexa: Cryptosporidiidae) in domestic mice (Mus musculus) [J].
Ren, Xupeng ;
Zhao, Jinfeng ;
Zhang, Longxian ;
Ning, Changshen ;
Jian, Fuchun ;
Wang, Rongjun ;
Lv, Chaochao ;
Wang, Qiang ;
Arrowood, Michael J. ;
Xiao, Lihua .
EXPERIMENTAL PARASITOLOGY, 2012, 130 (03) :274-281
[44]   Detection of zoonotic Cryptosporidium spp. in small wild rodents using amplicon-based next-generation sequencing [J].
Rotovnik, Rosalina ;
Lathrop, Tatiana Siegler ;
Skov, Jakob ;
Jokelainen, Pikka ;
Kapel, Christian Moliin Outzen ;
Stensvold, Christen Rune .
PARASITE EPIDEMIOLOGY AND CONTROL, 2024, 24
[45]   An Update on Zoonotic Cryptosporidium Species and Genotypes in Humans [J].
Ryan, Una ;
Zahedi, Alireza ;
Feng, Yaoyu ;
Xiao, Lihua .
ANIMALS, 2021, 11 (11)
[46]  
Sanchez Angie, 2017, Front Microbiol, V8, P248, DOI [10.3389/fmicb.2017.00248, 10.3389/fmicb.2017.00248]
[47]   Molecular Identification of Cryptosporidium viatorum Infection in a Patient Suffering from Unusual Cryptosporidiosis in West Bengal, India [J].
Sardar, Sanjib Kumar ;
Ghosal, Ajanta ;
Saito-Nakano, Yumiko ;
Dutta, Shanta ;
Nozaki, Tomoyoshi ;
Ganguly, Sandipan .
KOREAN JOURNAL OF PARASITOLOGY, 2021, 59 (04) :409-413
[48]   Development and Application of a gp60-Based Typing Assay for Cryptosporidium viatorum [J].
Stensvold, C. R. ;
Elwin, K. ;
Winiecka-Krusnell, J. ;
Chalmers, R. M. ;
Xiao, L. ;
Lebbad, M. .
JOURNAL OF CLINICAL MICROBIOLOGY, 2015, 53 (06) :1891-1897
[49]   Unique endemicity of Cryptosporidiosis in children in Kuwait [J].
Sulaiman, IM ;
Hira, PR ;
Zhou, L ;
Al-Ali, FM ;
Al-Shelahi, FA ;
Shweiki, HM ;
Iqbal, J ;
Khalid, N ;
Xiao, LH .
JOURNAL OF CLINICAL MICROBIOLOGY, 2005, 43 (06) :2805-2809
[50]  
Sulaiman IM, 2002, J PARASITOL, V88, P388, DOI 10.1645/0022-3395(2002)088[0388:MPAERO]2.0.CO