The role of mitophagy in metabolic diseases and its exercise intervention

被引：8
作者：
Tang, Shaokai [1 ]
Geng, Yuanwen [1 ]
Lin, Qinqin [1 ]
机构：
[1] Yanshan Univ, Sch Phys Educ, Qinhuangdao, Peoples R China
来源：
FRONTIERS IN PHYSIOLOGY | 2024年 / 15卷
基金：
中国国家自然科学基金;
关键词：
mitophagy; exercise; metabolic disease; mitochondrial dysfunction; exerkine; FATTY LIVER-DISEASE; ENERGY-METABOLISM; AUTOPHAGY; APOPTOSIS; MITOCHONDRIA; INFLAMMATION; DEGRADATION; MECHANISMS; EXPRESSION; PROTECTS;
D O I：
10.3389/fphys.2024.1339128
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Mitochondria are energy factories that sustain life activities in the body, and their dysfunction can cause various metabolic diseases that threaten human health. Mitophagy, an essential intracellular mitochondrial quality control mechanism, can maintain cellular and metabolic homeostasis by removing damaged mitochondria and participating in developing metabolic diseases. Research has confirmed that exercise can regulate mitophagy levels, thereby exerting protective metabolic effects in metabolic diseases. This article reviews the role of mitophagy in metabolic diseases, the effects of exercise on mitophagy, and the potential mechanisms of exercise-regulated mitophagy intervention in metabolic diseases, providing new insights for future basic and clinical research on exercise interventions to prevent and treat metabolic diseases.
引用
收藏
页数：20
相关论文
共 50 条
  • [31] The Role of Mitophagy in Innate Immunity
    Gkikas, Ilias
    Palikaras, Konstantinos
    Tavernarakis, Nektarios
    [J]. FRONTIERS IN IMMUNOLOGY, 2018, 9
  • [32] The immunomodulating role of exercise in metabolic disease
    Lancaster, Graeme I.
    Febbraio, Mark A.
    [J]. TRENDS IN IMMUNOLOGY, 2014, 35 (06) : 262 - 269
  • [33] The Role of Endothelial Cell Mitophagy in Age-Related Cardiovascular Diseases
    Han, Quancheng
    Yu, Yiding
    Liu, Xiujuan
    Guo, Yonghong
    Shi, Jingle
    Xue, Yitao
    Li, Yan
    [J]. AGING AND DISEASE, 2025,
  • [34] The role of FUNDC1 in mitophagy, mitochondrial dynamics and human diseases
    Liu, Hui
    Zang, Caixia
    Yuan, Fangyu
    Ju, Cheng
    Shang, Meiyu
    Ning, Jingwen
    Yang, Yang
    Ma, Jingwei
    Li, Gen
    Bao, Xiuqi
    Zhang, Dan
    [J]. BIOCHEMICAL PHARMACOLOGY, 2022, 197
  • [35] From macroautophagy to mitophagy: Unveiling the hidden role of mitophagy in gastrointestinal disorders
    Gao, Duo-Lun
    Lin, Meng-Ran
    Ge, Nan
    Guo, Jin-Tao
    Yang, Fan
    Sun, Si-Yu
    [J]. WORLD JOURNAL OF GASTROENTEROLOGY, 2024, 30 (23) : 2934 - 2946
  • [36] Emerging role of mitophagy in myoblast differentiation and skeletal muscle remodeling
    Rahman, F. Ahmad
    Quadrilatero, Joe
    [J]. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2023, 143 : 54 - 65
  • [37] Exercise during weight loss improves hepatic mitophagy
    Rosa-Caldwell, Megan E.
    Poole, Kaylee E.
    Seija, Andrew
    Harris, Matthew P.
    Greene, Nicholas P.
    Wooten, Joshua S.
    [J]. SPORTS MEDICINE AND HEALTH SCIENCE, 2022, 4 (03) : 183 - 189
  • [38] Bone metastases induce metabolic changes and mitophagy in mice
    Wilcox-Hagerty, Jenna
    Xu, Haifang
    Hain, Brian A.
    Arnold, Amy C.
    Waning, David L.
    [J]. EXPERIMENTAL PHYSIOLOGY, 2021, 106 (02) : 506 - 518
  • [39] Mitochondrial dysfunction as a driver of NLRP3 inflammasome activation and its modulation through mitophagy for potential therapeutics
    Mishra, Soumya Ranjan
    Mahapatra, Kewal Kumar
    Behera, Bishnu Prasad
    Patra, Srimanta
    Bhol, Chandra Sekhar
    Panigrahi, Debasna Pritimanjari
    Praharaj, Prakash Priyadarshi
    Singh, Amruta
    Patil, Shankargouda
    Dhiman, Rohan
    Bhutia, Sujit Kumar
    [J]. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2021, 136
  • [40] Mitophagy in fibrotic diseases: molecular mechanisms and therapeutic applications
    Cui, Xinyan
    Zhou, Zekun
    Tu, Hua
    Wu, Jianjun
    Zhou, Jian
    Yi, Qiao
    Liu, Ousheng
    Dai, Xiaohan
    [J]. FRONTIERS IN PHYSIOLOGY, 2024, 15
12345