The role of mitophagy in metabolic diseases and its exercise intervention

被引:8
作者
Tang, Shaokai [1 ]
Geng, Yuanwen [1 ]
Lin, Qinqin [1 ]
机构
[1] Yanshan Univ, Sch Phys Educ, Qinhuangdao, Peoples R China
基金
中国国家自然科学基金;
关键词
mitophagy; exercise; metabolic disease; mitochondrial dysfunction; exerkine; FATTY LIVER-DISEASE; ENERGY-METABOLISM; AUTOPHAGY; APOPTOSIS; MITOCHONDRIA; INFLAMMATION; DEGRADATION; MECHANISMS; EXPRESSION; PROTECTS;
D O I
10.3389/fphys.2024.1339128
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Mitochondria are energy factories that sustain life activities in the body, and their dysfunction can cause various metabolic diseases that threaten human health. Mitophagy, an essential intracellular mitochondrial quality control mechanism, can maintain cellular and metabolic homeostasis by removing damaged mitochondria and participating in developing metabolic diseases. Research has confirmed that exercise can regulate mitophagy levels, thereby exerting protective metabolic effects in metabolic diseases. This article reviews the role of mitophagy in metabolic diseases, the effects of exercise on mitophagy, and the potential mechanisms of exercise-regulated mitophagy intervention in metabolic diseases, providing new insights for future basic and clinical research on exercise interventions to prevent and treat metabolic diseases.
引用
收藏
页数:20
相关论文
共 50 条
  • [21] Role and Mechanisms of Mitophagy in Liver Diseases
    Ma, Xiaowen
    McKeen, Tara
    Zhang, Jianhua
    Ding, Wen-Xing
    CELLS, 2020, 9 (04)
  • [22] Autophagy and mitophagy in cancer metabolic remodelling
    Ferro, Fabio
    Servais, Stephane
    Besson, Pierre
    Roger, Sebastien
    Dumas, Jean-Francois
    Brisson, Lucie
    SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2020, 98 : 129 - 138
  • [23] The Effects of Asprosin on Exercise-Intervention in Metabolic Diseases
    Liu, Lifei
    Liu, Yuhao
    Huang, Mei
    Zhang, Miao
    Zhu, Chenyu
    Chen, Xi
    Bennett, Samuel
    Xu, Jiake
    Zou, Jun
    FRONTIERS IN PHYSIOLOGY, 2022, 13
  • [24] Mitophagy modulation for the treatment of cardiovascular diseases
    Forte, Maurizio
    D'Ambrosio, Luca
    Schiattarella, Gabriele G.
    Salerno, Nadia
    Perrone, Marco Alfonso
    Loffredo, Francesco S.
    Bertero, Edoardo
    Pilichou, Kalliopi
    Manno, Girolamo
    Valenti, Valentina
    Spadafora, Luigi
    Bernardi, Marco
    Simeone, Beatrice
    Sarto, Gianmarco
    Frati, Giacomo
    Perrino, Cinzia
    Sciarretta, Sebastiano
    EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2024, 54 (08)
  • [25] Differential Role of Active Compounds in Mitophagy and Related Neurodegenerative Diseases
    Makarov, Mark
    Korkotian, Eduard
    TOXINS, 2023, 15 (03)
  • [26] USP33 deubiquitinates PRKN/parkin and antagonizes its role in mitophagy
    Niu, Kaifeng
    Fang, Hongbo
    Chen, Zixiang
    Zhu, Yuqi
    Tan, Qunsong
    Wei, Di
    Li, Yueyang
    Balajee, Adayabalam S.
    Zhao, Yongliang
    AUTOPHAGY, 2020, 16 (04) : 724 - 734
  • [27] Role of AMBRA1 in mitophagy regulation: emerging evidence in aging-related diseases
    Di Rienzo, Martina
    Romagnoli, Alessandra
    Refolo, Giulia
    Vescovo, Tiziana
    Ciccosanti, Fabiola
    Zuchegna, Candida
    Lozzi, Francesca
    Occhigrossi, Luca
    Piacentini, Mauro
    Fimia, Gian Maria
    AUTOPHAGY, 2024, 20 (12) : 2602 - 2615
  • [28] Mitophagy in Human Diseases
    Doblado, Laura
    Lueck, Claudia
    Rey, Claudia
    Samhan-Arias, Alejandro K.
    Prieto, Ignacio
    Stacchiotti, Alessandra
    Monsalve, Maria
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (08)
  • [29] Mitophagy in Cardiovascular Diseases
    Morciano, Giampaolo
    Patergnani, Simone
    Bonora, Massimo
    Pedriali, Gaia
    Tarocco, Anna
    Bouhamida, Esmaa
    Marchi, Saverio
    Ancora, Gina
    Anania, Gabriele
    Wieckowski, Mariusz R.
    Giorgi, Carlotta
    Pinton, Paolo
    JOURNAL OF CLINICAL MEDICINE, 2020, 9 (03)
  • [30] Role of mitophagy in ocular neurodegeneration
    Brooks, Calvin D.
    Kodati, Bindu
    Stankowska, Dorota L.
    Krishnamoorthy, Raghu R.
    FRONTIERS IN NEUROSCIENCE, 2023, 17