The role of mitophagy in metabolic diseases and its exercise intervention

被引：8

作者：

Tang, Shaokai ^{[1
]}

Geng, Yuanwen ^{[1
]}

Lin, Qinqin ^{[1
]}

机构：

[1] Yanshan Univ, Sch Phys Educ, Qinhuangdao, Peoples R China

来源：

FRONTIERS IN PHYSIOLOGY | 2024年 / 15卷

基金：

中国国家自然科学基金;

关键词：

mitophagy; exercise; metabolic disease; mitochondrial dysfunction; exerkine; FATTY LIVER-DISEASE; ENERGY-METABOLISM; AUTOPHAGY; APOPTOSIS; MITOCHONDRIA; INFLAMMATION; DEGRADATION; MECHANISMS; EXPRESSION; PROTECTS;

D O I：

10.3389/fphys.2024.1339128

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Mitochondria are energy factories that sustain life activities in the body, and their dysfunction can cause various metabolic diseases that threaten human health. Mitophagy, an essential intracellular mitochondrial quality control mechanism, can maintain cellular and metabolic homeostasis by removing damaged mitochondria and participating in developing metabolic diseases. Research has confirmed that exercise can regulate mitophagy levels, thereby exerting protective metabolic effects in metabolic diseases. This article reviews the role of mitophagy in metabolic diseases, the effects of exercise on mitophagy, and the potential mechanisms of exercise-regulated mitophagy intervention in metabolic diseases, providing new insights for future basic and clinical research on exercise interventions to prevent and treat metabolic diseases.

引用

页数：20

共 50 条

[1] Dual Role of Mitophagy in Cardiovascular Diseases
Li, Yibo
Meng, Weizheng
Hou, Yaxin
Li, Dongxu
Wang, Xiulong
Wu, Kai
Sun, Siyu
Liu, Huibing
Li, Xuefang
Lin, Fei
Zhao, Guoan
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 2021, 78 (01) : 30 - 39
[2] Emerging Role of Mitophagy in Inflammatory Diseases: Cellular and Molecular Episodes
Adil, Mohamed A. A.
Ameenudeen, Shabnam
Kumar, Ashok
Hemalatha, S.
Ahmed, Neesar
Ali, Nemat
AlAsmari, Abdullah F.
Aashique, Mohammad
Waseem, Mohammad
CURRENT PHARMACEUTICAL DESIGN, 2020, 26 (04) : 485 - 491
[3] THE ROLE OF MITOPHAGY IN SELECTED NEURODEGENERATIVE DISEASES
Osuch, Bartosz
Kucharska, Teresa
Chmielewska, Natalia
Maciejak, Piotr
Szyndler, Janusz
Plaznik, Adam
POSTEPY PSYCHIATRII I NEUROLOGII, 2019, 28 (02): : 154 - 161
[4] Mitophagy mechanisms and role in human diseases
Redmann, Matthew
Dodson, Matthew
Boyer-Guittaut, Michael
Darley-Usmar, Victor
Zhang, Jianhua
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2014, 53 : 127 - 133
[5] The Emerging Role of FUNDC1-Mediated Mitophagy in Cardiovascular Diseases
Liu, Lei
Li, Yimei
Chen, Quan
FRONTIERS IN PHYSIOLOGY, 2021, 12
[6] Macrophage Polarization: Implications on Metabolic Diseases and the Role of Exercise
Sanches Silveira, Loreana
Mello Antunes, Barbara de Moura
Araujo Minari, Andre Luis
Thomatieli dos Santos, Ronaldo Vagner
Rosa Neto, Jose Cesar
Lira, Fabio Santos
CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION, 2016, 26 (02): : 115 - 132
[7] Role of DRAM1 in mitophagy contributes to preeclampsia regulation in mice
Chen, Guoqing
Lin, Ying
Chen, Lu
Zeng, Fa
Zhang, Li
Huang, Yan
Huang, Pingping
Liao, Lingling
Yu, Yuanlan
MOLECULAR MEDICINE REPORTS, 2020, 22 (03) : 1847 - 1858
[8] Mechanism of Mitophagy and Its Role in Sepsis Induced Organ Dysfunction: A Review
Zhu, Cheng-long
Yao, Ren-qi
Li, Lu-xi
Li, Peng
Xie, Jian
Wang, Jia-feng
Deng, Xiao-ming
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2021, 9
[9] Role of mitophagy in pulmonary hypertension: Targeting the mechanism and pharmacological intervention
Wan, Jia-Jing
Yi, Jian
Wang, Fei-Ying
Li, Xia
Zhang, Chao
Song, Lan
Dai, Ai-Guo
MITOCHONDRION, 2024, 78
[10] The Role of Autophagy and Mitophagy in Bone Metabolic Disorders
Wang, Shuai
Deng, Zhantao
Ma, Yuanchen
Jin, Jiewen
Qi, Fangjie
Li, Shuxian
Liu, Chang
Lyu, Feng-Juan
Zheng, Qiujian
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2020, 16 (14): : 2675 - 2691

← 1 2 3 4 5 →