Parkinson's disease motor progression in relation to the timing of REM sleep behavior disorder presentation: an exploratory retrospective study

被引：4

作者：

Bovenzi, Roberta ^{[1
]}

Pierantozzi, Mariangela ^{[1
,2
]}

Conti, Matteo ^{[1
]}

Carignani, Silvia ^{[1
]}

Fernandes, Mariana ^{[1
]}

Schirinzi, Tommaso ^{[1
,2
]}

Cerroni, Rocco ^{[2
]}

Mercuri, Nicola Biagio ^{[1
]}

Stefani, Alessandro ^{[1
,2
]}

Liguori, Claudio ^{[1
,2
,3
]}

机构：

[1] Univ Roma Tor Vergata, Dept Syst Med, Via Montpellier 1, I-00133 Rome, Italy

[2] Univ Hosp Rome Tor Vergata, Parkinsons Dis Unit, Via Montpellier 1, I-00133 Rome, Italy

[3] Univ Hosp Rome Vergata, Sleep Med Ctr, Via Montpellier 1, I-00133 Rome, Italy

来源：

JOURNAL OF NEURAL TRANSMISSION | 2024年 / 131卷 / 03期

关键词：

Parkinson's disease; REM sleep behavior disorder; Motor progression; H&Y scale; UPDRS; Body first; Brain first;

D O I：

10.1007/s00702-024-02739-5

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

REM sleep behavior disorder (RBD) is a frequent non-motor symptom of Parkinson's disease (PD), and the timing of its presentation might have a role in the underlying neurodegenerative process. Here, we aimed to define the potential impact of probable RBD (pRBD) on PD motor progression. We conducted a longitudinal retrospective study on 66 PD patients followed up at the University Hospital of Rome Tor Vergata. Patients were divided into three groups: with post-motor pRBD (pRBD(post), n = 25), without pRBD (pRBD(wo), n = 20), and with pre-motor pRBD (pRBD(pre), n = 21). Hoehn and Yahr (H&Y) scores, Unified PD Rating Scale (UPDRS) motor scores, and levodopa equivalent daily dose were collected at two follow-up visits conducted in a 5-year interval (T0 and T1). pRBD(post )patients had a greater rate of motor progression in terms of the H&Y scale compared to pRBD(pre) and pRBD(wo) patients, without the influence of anti-parkinsonian treatment. These preliminary findings suggest that the post-motor occurrence of pRBD can be associated with an acceleration in PD motor progression.

引用

页码：239 / 244

页数：6

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