Pharmacological Advances of Coumarin and Its Derivatives

被引：0

作者：

Jin, Jie ^{[1
]}

Li, Huijin ^{[2
]}

Li, Pengquan ^{[2
]}

Xing, Lu ^{[2
]}

Huang, Xiaoqiang ^{[3
]}

Zhang, Jie ^{[3
]}

Zhou, Xin ^{[2
]}

Qin, Wei ^{[2
]}

He, Chunxia ^{[2
]}

Zhao, Dong ^{[2
]}

Chu, Haiqing ^{[2
]}

Ma, Yi ^{[3
]}

Cao, Huiling ^{[2
,3
]}

机构：

[1] Shaanxi Univ Chinese Med, Dept Pharm, Xianyang 712046, Shaanxi, Peoples R China

[2] Xian Med Univ, Coll Pharm, Xian Key Lab Basic & Translat Cardiovasc Metab Dis, Xian 710021, Shaanxi, Peoples R China

[3] Xian Fifth Hosp, Xian 710082, Shaanxi, Peoples R China

来源：

INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2023年 / 85卷 / 03期

基金：

芬兰科学院; 中国国家自然科学基金;

关键词：

Coumarin; coronavirus disease-19; rheumatoid arthritis; autoimmune neuroinflammation; systemic lupus erythematosus; idiopathic pulmonary fibrosis; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; IN-VITRO; CELLS; APOPTOSIS; OSTHOLE; ANGIOGENESIS; ANTIOXIDANT; INHIBITION; INDUCTION; MECHANISM;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Coumarin is a kind of lactone compound with skeleton of benzo-alpha-pyranones, which have favorable druggability due to its advantages of outstanding pharmacological activities, little drug-resistance, low toxicity, simple skeleton, easy synthesis and structural modification, and extensive sources. The review summarizes the classification, synthesis methods, pharmacological effects of coumarin and its derivatives. It focuses on their latest progresses in anti-bacteria, anti-virus, anti-inflammation and anti-rheumatism, anti-autoimmune diseases, anti-oxidation, anti-coagulation, anti-cancer and antiangiogenic effects in detail. Especially, coumarins exhibited outstanding effects on clinical difficult miscellaneous diseases with rare drugs, difficult cure and bad prognosis, such as coronavirus disease-19, rheumatoid arthritis, autoimmune neuroinflammation, systemic lupus erythematosus, idiopathic pulmonary fibrosis, etc. The review would provide new skeletons and promising lead compounds with little drug-resistance, high-efficiency and low toxicity for new drug development for related diseases based on coumarins.

引用

页码：565 / 580

页数：16

共 99 条

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