Do SARS-CoV-2 Variants Differ in Their Neuropathogenicity?

被引：5

作者：

Bauer, Lisa ^{[1
]}

van Riel, Debby ^{[1
]}

机构：

[1] Erasmus MC, Dept Virosci, Rotterdam, Netherlands

来源：

MBIO | 2023年 / 14卷 / 01期

关键词：

neuropathogenesis; neuroinvasion; neurotropism; neurovirulence; CNS; astrocytes; SARS-CoV-2; Omicron; Delta; D614G; ACE2; NRP1; INFECTION; COVID-19;

D O I：

10.1128/mbio.02920-22

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Neurological complications associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections are a huge societal problem. Although the neuropathogenicity of SARS-CoV-2 is not yet fully understood, there is evidence that SARS-CoV-2 can invade and infect cells of the central nervous system. Kong et al. (https://doi.org/10 .1128/mbio.02308-22) shows that the mechanism of virus entry into astrocytes in brain organoids and primary astrocytes differs from entry into respiratory epithelial cells. However, how SARS-CoV-2 enters susceptible CNS cells and whether there are differences among SARS-CoV-2 variants is still unclear. In vivo and in vitro models are useful to study these important questions and may reveal important differences among SARS-CoV-2 variants in their neuroinvasive, neurotropic, and neurovirulent potential. In this commentary we address how this study contributes to the understanding of the neuropathology of SARS-CoV-2 and its variants.

引用

页数：5

共 40 条

[1] The omicron (B.1.1.529) SARS-CoV-2 variant of concern does not readily infect Syrian hamsters [J].

Abdelnabi, Rana ;

Foo, Caroline S. ;

Zhang, Xin ;

Lemmens, Viktor ;

Maes, Piet ;

Slechten, Bram ;

Raymenants, Joren ;

Andr, Emmanuel ;

Weynand, Birgit ;

Dallmeier, Kai ;

Neyts, Johan .

ANTIVIRAL RESEARCH, 2022, 198

[2] Anti-SARS-CoV-2 antibodies in the CSF, blood-brain barrier dysfunction, and neurological outcome [J].

Alexopoulos, Harry ;

Magira, Eleni ;

Bitzogli, Kleopatra ;

Kafasi, Nikolitsa ;

Vlachoyiannopoulos, Panayiotis ;

Tzioufas, Athanasios ;

Kotanidou, Anastasia ;

Dalakas, Marinos C. .

NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION, 2020, 7 (06)

[3] Tropism of SARS-CoV-2 for human cortical astrocytes [J].

Andrews, Madeline G. ;

Mukhtar, Tanzila ;

Eze, Ugomma C. ;

Simoneau, Camille R. ;

Ross, Jayden ;

Parikshak, Neelroop ;

Wang, Shaohui ;

Zhou, Li ;

Koontz, Mark ;

Velmeshev, Dmitry ;

Siebert, Clara-Vita ;

Gemenes, Kaila M. ;

Tabata, Takako ;

Perez, Yonatan ;

Wang, Li ;

Mostajo-Radji, Mohammed A. ;

de Majo, Martina ;

Donohue, Kevin C. ;

Shin, David ;

Salma, Jahan ;

Pollen, Alex A. ;

Nowakowski, Tomasz J. ;

Ullian, Erik ;

Kumar, G. Renuka ;

Winkler, Ethan A. ;

Crouch, Elizabeth E. ;

Ott, Melanie ;

Kriegstein, Arnold R. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2022, 119 (30)

[4] Anosmia in COVID-19 Associated with Injury to the Olfactory Bulbs Evident on MRI [J].

Aragao, M. F. V. V. ;

Leal, M. C. ;

Cartaxo Filho, O. Q. ;

Fonseca, T. M. ;

Valenca, M. M. .

AMERICAN JOURNAL OF NEURORADIOLOGY, 2020, 41 (09) :1703-1706

[5] SARS-CoV-2 Omicron variant causes mild pathology in the upper and lower respiratory tract of hamsters [J].

Armando, Federico ;

Beythien, Georg ;

Kaiser, Franziska K. ;

Allnoch, Lisa ;

Heydemann, Laura ;

Rosiak, Malgorzata ;

Becker, Svenja ;

Gonzalez-Hernandez, Mariana ;

Lamers, Mart M. ;

Haagmans, Bart L. ;

Guilfoyle, Kate ;

van Amerongen, Geert ;

Ciurkiewicz, Malgorzata ;

Osterhaus, Albert D. M. E. ;

Baumgaertner, Wolfgang .

NATURE COMMUNICATIONS, 2022, 13 (01)

[6] In vitro and in vivo differences in neurovirulence between D614G, Delta And Omicron BA.1 SARS-CoV-2 variants [J].

Bauer, Lisa ;

Rissmann, Melanie ;

Benavides, Feline F. W. ;

Leijten, Lonneke ;

van Run, Peter ;

Begeman, Lineke ;

Veldhuis Kroeze, Edwin J. B. ;

Lendemeijer, Bas ;

Smeenk, Hilde ;

de Vrij, Femke M. S. ;

Kushner, Steven A. ;

Koopmans, Marion P. G. ;

Rockx, Barry ;

van Riel, Debby .

ACTA NEUROPATHOLOGICA COMMUNICATIONS, 2022, 10 (01)

[7] The neuroinvasiveness, neurotropism, and neurovirulence of SARS-CoV-2 [J].

Bauer, Lisa ;

Laksono, Brigitta M. ;

de Vrij, Femke M. S. ;

Kushner, Steven A. ;

Harschnitz, Oliver ;

van Riel, Debby .

TRENDS IN NEUROSCIENCES, 2022, 45 (05) :358-368

[8] Massive transient damage of the olfactory epithelium associated with infection of sustentacular cells by SARS-CoV-2 in golden Syrian hamsters [J].

Bryche, Bertrand ;

St Albin, Audrey ;

Murri, Severine ;

Lacote, Sandra ;

Pulido, Coralie ;

Gouilh, Meriadeg Ar ;

Lesellier, Sandrine ;

Servat, Alexandre ;

Wasniewski, Marine ;

Picard-Meyer, Evelyne ;

Monchatre-Leroy, Elodie ;

Volmer, Romain ;

Rampin, Olivier ;

Le Goffic, Ronan ;

Marianneau, Philippe ;

Meunier, Nicolas .

BRAIN BEHAVIOR AND IMMUNITY, 2020, 89 :579-586

[9] Olfactory dysfunction in COVID-19: new insights into the underlying mechanisms [J].

Butowt, Rafal ;

Bilinska, Katarzyna ;

von Bartheld, Christopher S. .

TRENDS IN NEUROSCIENCES, 2023, 46 (01) :75-90

[10] Fatal Neurodissemination and SARS-CoV-2 Tropism in K18-hACE2 Mice Is Only Partially Dependent on hACE2 Expression [J].

Carossino, Mariano ;

Kenney, Devin ;

O'Connell, Aoife K. ;

Montanaro, Paige ;

Tseng, Anna E. ;

Gertje, Hans P. ;

Grosz, Kyle A. ;

Ericsson, Maria ;

Huber, Bertrand R. ;

Kurnick, Susanna A. ;

Subramaniam, Saravanan ;

Kirkland, Thomas A. ;

Walker, Joel R. ;

Francis, Kevin P. ;

Klose, Alexander D. ;

Paragas, Neal ;

Bosmann, Markus ;

Saeed, Mohsan ;

Balasuriya, Udeni B. R. ;

Douam, Florian ;

Crossland, Nicholas A. .

VIRUSES-BASEL, 2022, 14 (03)

← 1 2 3 4 →