Chrysin inhibits the cell viability, induces apoptosis and modulates expression of genes related to epigenetic events in bladder cancer cells

被引：0

作者：

Braga Lima, Ana Paula ^{[1
,2
]}

Melo, Andre Sacramento ^{[2
]}

Ferreira, Gabriel Monteze ^{[1
,2
]}

da Silva, Glenda Nicioli ^{[1
,2
,3
]}

机构：

[1] Univ Fed Ouro Preto, Programa Posgrad Ciencias Farmaceut CIPHARMA, Ouro Preto, Brazil

[2] Univ Fed Ouro Preto, Dept Anal Clin, Lab Pesquisas Clin, Escola Farm, Ouro Preto, Brazil

[3] Univ Fed Ouro Preto, Programa Posgrad Ciencias Biol CBIOL, Ouro Preto, Brazil

来源：

NATURAL PRODUCT RESEARCH | 2023年 / 37卷 / 11期

关键词：

Flavonoid; bladder tumor; cell death; epigenetic events; TP53; IDN; CYTOTOXICITY; CARCINOMA; STEP;

D O I：

10.1080/14786419.2022.2121825

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

This study was conducted with the aim of exploring the molecular and cellular mechanisms of action of the chrysin (natural flavonoid compound) on bladder tumour cell lines with different status of TP53 (RT4, 5637 and T24). The cells were treated with different concentrations of chrysin (20, 40, 60, 80 and 100 mu M) to analyze the cell viability, nuclear division index, mutagenicity, apoptosis rates and expression of genes related to epigenetic events (DNMT1, HAT1 and HDAC1). Results showed that the treatment with chrysin reduced the cell viability and caused apoptosis, regardless TP53. Moreover, in the TP53-mutated cell lines, chrysin modulated the expression of the DNMT1, HAT1 and HDAC1 epigenetic genes, which might be a plus to the death observed in the cells with p53 mutation.

引用

页码：1877 / 1881

页数：5

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