Olovnikov, Telomeres, and Telomerase. Is It Possible to Prolong a Healthy Life?

被引：1

作者：

Yegorov, Yegor E. ^{[1
]}

机构：

[1] Russian Acad Sci, Engelhardt Inst Mol Biol, Moscow 119991, Russia

来源：

BIOCHEMISTRY-MOSCOW | 2023年 / 88卷 / 11期

关键词：

telomeres; telomerase; aging; carcinogenesis; Olovnikov; telomere crisis; cell senescence; inflammatory aging; genetic instability; REPEAT-CONTAINING RNA; REVERSE-TRANSCRIPTASE; DNA-DAMAGE; CELLULAR SENESCENCE; CATALYTIC SUBUNIT; CANCER; MUTATIONS; FIBROBLASTS; EXPRESSION; COMPONENT;

D O I：

10.1134/S0006297923110032

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The science of telomeres and telomerase has made tremendous progress in recent decades. In this review, we consider it first in a historical context (the Carrel-Hayflick-Olovnikov-Blackburn chain of discoveries) and then review current knowledge on the telomere structure and dynamics in norm and pathology. Central to the review are consequences of the telomere shortening, including telomere position effects, DNA damage signaling, and increased genetic instability. Cell senescence and role of telomere length in its development are discussed separately. Therapeutic aspects and risks of telomere lengthening methods including use of telomerase and other approaches are also discussed.

引用

页码：1704 / 1718

页数：15

共 145 条

[1]

Abreu E, 2017, METHODS MOL BIOL, V1587, P113, DOI 10.1007/978-1-4939-6892-3_11

[2] Inhibition of DNA damage response at telomeres improves the detrimental phenotypes of Hutchinson-Gilford Progeria Syndrome [J].

Aguado, Julio ;

Sola-Carvajal, Agustin ;

Cancila, Valeria ;

Revechon, Gwladys ;

Ong, Peh Fern ;

Jones-Weinert, Corey Winston ;

Arzt, Emelie Wallen ;

Lattanzi, Giovanna ;

Dreesen, Oliver ;

Tripodo, Claudio ;

Rossiello, Francesca ;

Eriksson, Maria ;

di Fagagna, Fabrizio d'Adda .

NATURE COMMUNICATIONS, 2019, 10 (1)

[3] Reactivation of telomerase in cancer [J].

Akincilar, Semih Can ;

Unal, Bilal ;

Tergaonkar, Vinay .

CELLULAR AND MOLECULAR LIFE SCIENCES, 2016, 73 (08) :1659-1670

[4] Telomeric repeat-containing RNA and RNA surveillance factors at mammalian chromosome ends [J].

Azzalin, Claus M. ;

Reichenbach, Patrick ;

Khoriauli, Lela ;

Giulotto, Elena ;

Lingner, Joachim .

SCIENCE, 2007, 318 (5851) :798-801

[5] Genes and pathways downstream of telomerase in melanoma metastasis [J].

Bagheri, Sepideh ;

Nosrati, Mehdi ;

Li, Shang ;

Fong, Sylvia ;

Torabian, Sima ;

Rangel, Javier ;

Moore, Dan H. ;

Federman, Scot ;

LaPosa, Rebecca R. ;

Baehner, Frederick L. ;

Sagebiel, Richard W. ;

Cleaver, James E. ;

Haqq, Christopher ;

Debs, Robert J. ;

Blackburn, Elizabeth H. ;

Kashani-Sabet, Mohammed .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (30) :11306-11311

[6] Systematic analysis of telomere length and somatic alterations in 31 cancer types [J].

Barthel, Floris P. ;

Wei, Wei ;

Tang, Ming ;

Martinez-Ledesma, Emmanuel ;

Hu, Xin ;

Amin, Samirkumar B. ;

Akdemir, Kadir C. ;

Seth, Sahil ;

Song, Xingzhi ;

Wang, Qianghu ;

Lichtenberg, Tara ;

Hu, Jian ;

Zhang, Jianhua ;

Zheng, Siyuan ;

Verhaak, Roel G. W. .

NATURE GENETICS, 2017, 49 (03) :349-357

[7] Telomere position effect in human cells [J].

Baur, JA ;

Zou, Y ;

Shay, JW ;

Wright, WE .

SCIENCE, 2001, 292 (5524) :2075-2077

[8] Activation of telomerase by TA-65 enhances immunity and reduces inflammation post myocardial infarction [J].

Bawamia, Bilal ;

Spray, Luke ;

Wangsaputra, Vincent. K. K. ;

Bennaceur, Karim ;

Vahabi, Sharareh ;

Stellos, Konstantinos ;

Kharatikoopaei, Ehsan ;

Ogundimu, Emmanuel ;

Gale, Chris. P. P. ;

Keavney, Bernard ;

Maier, Rebecca ;

Hancock, Helen ;

Richardson, Gavin ;

Austin, David ;

Spyridopoulos, Ioakim .

GEROSCIENCE, 2023, 45 (04) :2689-2705

[9] Alexis Carrel: the good, the bad, the ugly [J].

Benveniste, Glen L. .

ANZ JOURNAL OF SURGERY, 2013, 83 (09) :609-611

[10] Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer [J].

Bernardes de Jesus, Bruno ;

Vera, Elsa ;

Schneeberger, Kerstin ;

Tejera, Agueda M. ;

Ayuso, Eduard ;

Bosch, Fatima ;

Blasco, Maria A. .

EMBO MOLECULAR MEDICINE, 2012, 4 (08) :691-704

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