Thrombotic Microangiopathy in the Renal Allograft: Results of the TMA Banff Working Group Consensus on Pathologic Diagnostic Criteria

被引：10

作者：

Afrouzian, Marjan ^{[1
]}

Kozakowski, Nicolas ^{[2
]}

Liapis, Helen ^{[3
,4
]}

Broecker, Verena ^{[5
]}

Truong, Luon ^{[6
]}

Avila-Casado, Carmen ^{[7
]}

Regele, Heinz ^{[2
]}

Seshan, Surya ^{[8
]}

Ambruzs, Josephine M. ^{[9
]}

Farris, Alton Brad ^{[10
]}

Buob, David ^{[11
]}

Chander, Praveen N. ^{[12
]}

Cheraghvandi, Lukman ^{[13
]}

Clahsen-van Groningen, Marian C. ^{[14
,15
]}

Araujo, Stanley de Almeida ^{[16
]}

Baydar, Dilek Ertoy ^{[17
]}

Formby, Mark ^{[18
,19
]}

Ljubanovic, Danica Galesic ^{[20
]}

Hernandez, Loren Herrera ^{[21
]}

Honsova, Eva ^{[22
]}

Mohamed, Nasreen ^{[23
]}

Ozluk, Yasemin ^{[24
]}

Rabant, Marion ^{[25
]}

Royal, Virginie ^{[26
]}

Stevenson, Heather L. ^{[1
]}

Toniolo, Maria Fernanda ^{[27
]}

Taheri, Diana ^{[28
]}

机构：

[1] Univ Texas Med Branch Galveston, John Sealy Sch Med, Dept Radiol, Galveston, TX 77555 USA

[2] Med Univ Vienna, Dept Pathol, Vienna, Austria

[3] Washington Univ, Dept Pathol & Immunol, Sch Med, St Louis, MO USA

[4] Ludwig Maximilians Univ Munchen, Dept Nephrol, Munich, Germany

[5] Sahlgrens Univ Hosp, Dept Clin Pathol, Gothenburg, Sweden

[6] Houston Methodist Hosp, Dept Pathol, Houston, TX USA

[7] Univ Hlth Network UHN, Lab Med Program, Toronto, ON, Canada

[8] Weill Cornell Med, Dept Pathol & Lab Med, New York, NY USA

[9] Arkana Labs, Little Rock, AR USA

[10] Emory Univ, Dept Pathol & Lab Med, Atlanta, GA USA

[11] Sorbonne Univ, Assistance Publ Hop Paris, Dept Pathol, Hop Tenon, Paris, France

[12] New York Med Coll, Valhalla, NY USA

[13] Baylor Coll Med, Dept Pathol & Immunol, Houston, TX USA

[14] Univ Med Ctr Rotterdam, Erasmus MC Transplant Inst, Dept Pathol & Clin Bioinformat, Rotterdam, Netherlands

[15] Rhein Westfal TH Aachen, Inst Expt Med & Syst Biol, Aachen, Germany

[16] Univ Fed Minas Gerais, Dept Parasitol, Inst Ciencias Biol, Belo Horizonte, MG, Brazil

[17] Koc Univ, Sch Med, Dept Physiol, Sariyer, Turkiye

[18] NSW Hlth Pathol, Dept Anat Pathol, Sydney, NSW, Australia

[19] Univ Newcastle, Sch Med & Publ Hlth, Callaghan, NSW, Australia

[20] Univ Zagreb, Sch Med, Dept Pathol, Zagreb, Croatia

[21] Mayo Clin, Dept Pathol & Lab Med, Rochester, MN USA

[22] Charles Univ Prague, AeskuLab Pathol & Dept Pathol, Prague, Czech Republic

[23] King Fahad Specialist Hosp Dammam, Dept Pathol & Lab Med, Dammam, Saudi Arabia

[24] Istanbul Univ, Istanbul Fac Med, Dept Pathol, Istanbul, Turkiye

[25] Univ Paris Cite, Necker Enfants Malad Hosp, Dept Pathol, Paris, France

[26] Univ Montreal, Maisonneuve Rosemont Hosp, Dept Pathol, Montreal, PQ, Canada

[27] Inst Nefrol Nephrol, Kidney Pancreas Transplantat, Buenos Aires, Argentina

[28] Isfahan Univ Med Sci, Isfahan Kidney Dis Res Ctr, Dept Pathol, Esfahan, Iran

来源：

TRANSPLANT INTERNATIONAL | 2023年 / 36卷

关键词：

thrombotic microangiopathy; kidney; transplant; pathology criteria; Delphi; Banff; ANTIBODY-MEDIATED REJECTION; DELPHI; C4D; TRANSPLANTATION; CLASSIFICATION; EXPRESSION; PROSPECTS;

D O I：

10.3389/ti.2023.11590

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

The Banff community summoned the TMA Banff Working Group to develop minimum diagnostic criteria (MDC) and recommendations for renal transplant TMA (Tx-TMA) diagnosis, which currently lacks standardized criteria. Using the Delphi method for consensus generation, 23 nephropathologists (panelists) with >3 years of diagnostic experience with Tx-TMA were asked to list light, immunofluorescence, and electron microscopic, clinical and laboratory criteria and differential diagnoses for Tx-TMA. Delphi was modified to include 2 validations rounds with histological evaluation of whole slide images of 37 transplant biopsies (28 TMA and 9 non-TMA). Starting with 338 criteria in R1, MDC were narrowed down to 24 in R8 generating 18 pathological, 2 clinical, 4 laboratory criteria, and 8 differential diagnoses. The panelists reached a good level of agreement (70%) on 76% of the validated cases. For the first time in Banff classification, Delphi was used to reach consensus on MDC for Tx-TMA. Phase I of the study (pathology phase) will be used as a model for Phase II (nephrology phase) for consensus regarding clinical and laboratory criteria. Eventually in Phase III (consensus of the consensus groups) and the final MDC for Tx-TMA will be reported to the transplantation community.

引用

页数：10

共 34 条

[11] Neoplastic cell percentage estimation in tissue samples for molecular oncology: recommendations from a modified Delphi study
Dufraing, Kelly
van Krieken, J. Henricus
De Hertogh, Gert
Hoefler, Gerald
Oniscu, Anca
Kuhlmann, Tine P.
Weichert, Wilko
Marchio, Caterina
Ristimaki, Ari
Ryska, Ales
Scoazec, Jean-Yves
Dequeker, Elisabeth
[J]. HISTOPATHOLOGY, 2019, 75 (03) : 312 - 319
[12] Increased risk of thrombotic microangiopathy in patients receiving a cyclosporin-sirolimus combination
Fortin, MC
Raymond, MA
Madore, F
Fugère, JA
Pâquet, M
St-Louis, G
Hébert, MJ
[J]. AMERICAN JOURNAL OF TRANSPLANTATION, 2004, 4 (06) : 946 - 952
[13] Diagnosis, Education, and Care of Patients with APOL1-Associated Nephropathy: A Delphi Consensus and Systematic Review
Freedman, Barry I.
Burke, Wylie
Divers, Jasmin
Eberhard, Lucy
Gadegbeku, Crystal A.
Gbadegesin, Rasheed
Hall, Michael E.
Jones-Smith, Tiffany
Knight, Richard
Kopp, Jeffrey B.
Kovesdy, Csaba P.
Norris, Keith C.
Olabisi, Opeyemi A.
Roberts, Glenda V.
Sedor, John R.
Blacksher, Erika
[J]. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2021, 32 (07): : 1765 - 1778
[14] George JN, 2014, NEW ENGL J MED, V371, P654, DOI [10.1056/NEJMc1410951, 10.1056/NEJMra1312353]
[15] Applying the Delphi technique in a study of GPs' information requirements
Green, B
Jones, M
Hughes, D
Williams, A
[J]. HEALTH & SOCIAL CARE IN THE COMMUNITY, 1999, 7 (03) : 198 - 205
[16] De Novo Hemolytic Uremic Syndrome/Thrombotic Microangiopathy After Renal Transplantation: A Single Centre Experience
Gumber, M.
Vanikar, A.
Kute, V.
Shah, P.
Patel, H.
Engineer, D.
Trivedi, H.
Modi, P.
[J]. TRANSPLANTATION, 2014, 98 : 259 - 259
[17] The Banff 2017 Kidney Meeting Report: Revised diagnostic criteria for chronic active T cell-mediated rejection, antibody-mediated rejection, and prospects for integrative endpoints for next-generation clinical trials
Haas, M.
Loupy, A.
Lefaucheur, C.
Roufosse, C.
Glotz, D.
Seron, D.
Nankivell, B. J.
Halloran, P. F.
Colvin, R. B.
Akalin, Enver
Alachkar, N.
Bagnasco, S.
Bouatou, Y.
Becker, J. U.
Cornell, L. D.
van Huyen, J. P. Duong
Gibson, I. W.
Kraus, Edward S.
Mannon, R. B.
Naesens, M.
Nickeleit, V.
Nickerson, P.
Segev, D. L.
Singh, H. K.
Stegall, M.
Randhawa, P.
Racusen, L.
Solez, K.
Mengel, M.
[J]. AMERICAN JOURNAL OF TRANSPLANTATION, 2018, 18 (02) : 293 - 307
[18] Banff 2013 Meeting Report: Inclusion of C4d-Negative Antibody-Mediated Rejection and Antibody-Associated Arterial Lesions
Haas, M.
Sis, B.
Racusen, L. C.
Solez, K.
Glotz, D.
Colvin, R. B.
Castro, M. C. R.
David, D. S. R.
David-Neto, E.
Bagnasco, S. M.
Cendales, L. C.
Cornell, L. D.
Demetris, A. J.
Drachenberg, C. B.
Farver, C. F.
Farris, A. B., III
Gibson, I. W.
Kraus, E.
Liapis, H.
Loupy, A.
Nickeleit, V.
Randhawa, P.
Rodriguez, E. R.
Rush, D.
Smith, R. N.
Tan, C. D.
Wallace, W. D.
Mengel, M.
[J]. AMERICAN JOURNAL OF TRANSPLANTATION, 2014, 14 (02) : 272 - 283
[19] Consensus definitions for glomerular lesions by light and electron microscopy: recommendations from a working group of the Renal Pathology Society
Haas, Mark
Seshan, Surya V.
Barisoni, Laura
Amann, Kerstin
Bajema, Ingeborg M.
Becker, Jan Ulrich
Joh, Kensuke
Ljubanovic, Danica
Roberts, Ian S. D.
Roelofs, Joris J.
Sethi, Sanjeev
Zeng, Caihong
Jennette, J. Charles
[J]. KIDNEY INTERNATIONAL, 2020, 98 (05) : 1120 - 1134
[20] The Use of the Delphi and Other Consensus Group Methods in Medical Education Research: A Review
Humphrey-Murto, Susan
Varpio, Lara
Wood, Timothy J.
Gonsalves, Carol
Ufholz, Lee-Anne
Mascioli, Kelly
Wang, Carol
Foth, Thomas
[J]. ACADEMIC MEDICINE, 2017, 92 (10) : 1491 - 1498

← 1 2 3 4 →