Enantioselective Ni-Catalyzed Three-Component Dicarbofunctionalization of Alkenes

被引：23

作者：

Dong, Zhan ^{[1
]}

Song, Liangliang ^{[2
]}

Chen, Liang-An ^{[1
]}

机构：

[1] Nanjing Normal Univ, Jiangsu Collaborat Innovat Ctr Biomed Funct Mat, Sch Chem & Mat Sci, Jiangsu Key Lab New Power Batteries, Nanjing 210023, Peoples R China

[2] Nanjing Forestry Univ, Coll Chem Engn, Jiangsu Coinnovat Ctr Efficient Proc & Utilizat Fo, Nanjing 210037, Peoples R China

来源：

CHEMCATCHEM | 2023年 / 15卷 / 18期

基金：

中国国家自然科学基金;

关键词：

Asymmetric; Nickel Catalysis; Alkenes; Three Component; Dicarbofunctionalization; MULTICOMPONENT REACTIONS; REDUCTIVE DICARBOFUNCTIONALIZATION; COUPLING REACTIONS; NICKEL; PALLADIUM; DIFUNCTIONALIZATION; FUNCTIONALIZATION; HALIDES; COPPER; 1,1-DIARYLATION;

D O I：

10.1002/cctc.202300803

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Asymmetric multicomponent reactions are considered as efficient protocols for constructing complex chiral molecules because of their step- and atom-economy. Nickel-catalyzed asymmetric three-component dicarbofunctionalization of alkenes has been well developed in recent years, which is used in the area of total synthesis of natural products and late-stage modification of drugs because of the rapid incorporation of chiral sp(3)-enriched carbon centers. In this concept, the significant breakthroughs of this field are summarized, together with the related mechanisms. Moreover, the remaining challenges and potential opportunities of multicomponent dicarbofunctionalization are also highlighted.

引用

页数：9

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