The Devastating Effects of Sleep Deprivation on Memory: Lessons from Rodent Models

被引：19

作者：

Chen, Pinqiu ^{[1
,2
]}

Ban, Weikang ^{[1
]}

Wang, Wenyan ^{[2
]}

You, Yuyang ^{[3
]}

Yang, Zhihong ^{[1
]}

机构：

[1] Chinese Acad Med Sci & Peking Union Med Coll, Inst Med Plant Dev, Beijing 100193, Peoples R China

[2] Yantai Univ, Sch Pharm, Key Lab Mol Pharmacol & Drug Evaluat, Minist Educ, Yantai 264005, Peoples R China

[3] Beijing Inst Technol, Sch Automat, Beijing 100081, Peoples R China

来源：

CLOCKS & SLEEP | 2023年 / 5卷 / 02期

基金：

中国国家自然科学基金; 北京市自然科学基金;

关键词：

sleep deprivation; memory impairment; hippocampus; mechanism; progress; LONG-TERM POTENTIATION; PREFRONTAL CORTEX; CIRCADIAN-RHYTHMS; HIPPOCAMPAL-NEURONS; COGNITIVE FUNCTION; OXIDATIVE STRESS; REGULAR EXERCISE; OPERANT MEMORY; IMPAIRMENT; BRAIN;

D O I：

10.3390/clockssleep5020022

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In this narrative review article, we discuss the role of sleep deprivation (SD) in memory processing in rodent models. Numerous studies have examined the effects of SD on memory, with the majority showing that sleep disorders negatively affect memory. Currently, a consensus has not been established on which damage mechanism is the most appropriate. This critical issue in the neuroscience of sleep remains largely unknown. This review article aims to elucidate the mechanisms that underlie the damaging effects of SD on memory. It also proposes a scientific solution that might explain some findings. We have chosen to summarize literature that is both representative and comprehensive, as well as innovative in its approach. We examined the effects of SD on memory, including synaptic plasticity, neuritis, oxidative stress, and neurotransmitters. Results provide valuable insights into the mechanisms by which SD impairs memory function.

引用

页码：276 / 294

页数：19

共 204 条

[21] Astrocytes: Powering Memory [J].

Bezzi, Paola ;

Volterra, Andrea .

CELL, 2011, 144 (05) :644-645

[22] The CB1 cannabinoid receptor signals striatal neuroprotection via a PI3K/Akt/mTORC1/BDNF pathway [J].

Blazquez, C. ;

Chiarlone, A. ;

Bellocchio, L. ;

Resel, E. ;

Pruunsild, P. ;

Garcia-Rincon, D. ;

Sendtner, M. ;

Timmusk, T. ;

Lutz, B. ;

Galve-Roperh, I. ;

Guzman, M. .

CELL DEATH AND DIFFERENTIATION, 2015, 22 (10) :1618-1629

[23] BEHAVIORAL AND NEUROCHEMICAL EFFECTS OF DIETARY TYROSINE IN YOUNG AND AGED MICE FOLLOWING COLD-SWIM STRESS [J].

BRADY, K ;

BROWN, JW ;

THURMOND, JB .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1980, 12 (05) :667-674

[24] Sleep deprivation-induced pre- and postsynaptic modulation of orexin neurons [J].

Briggs, Chantalle ;

Bowes, Sherri C. ;

Semba, Kazue ;

Hirasawa, Michiru .

NEUROPHARMACOLOGY, 2019, 154 :50-60

[25] Sleep deprivation impairs long-term potentiation in rat hippocampal slices [J].

Campbell, IG ;

Guinan, MJ ;

Horowitz, JM .

JOURNAL OF NEUROPHYSIOLOGY, 2002, 88 (02) :1073-1076

[26] NEUROTRANSMITTER STUDIES OF NEUROENDOCRINE PATHOLOGY IN DEPRESSION [J].

CARROLL, BJ ;

GREDEN, JF ;

HASKETT, R ;

FEINBERG, M ;

ALBALA, AA ;

MARTIN, FIR ;

RUBIN, RT ;

HEATH, B ;

SHARP, PT ;

MCLEOD, WL ;

MCLEOD, MF .

ACTA PSYCHIATRICA SCANDINAVICA, 1980, 61 :183-199

[27] Ciproxifan improves working memory through increased prefrontal cortex neural activity in sleep-restricted mice [J].

Chauveau, F. ;

Laudereau, K. ;

Libourel, P. A. ;

Gervasoni, D. ;

Thomasson, J. ;

Poly, B. ;

Pierard, C. ;

Beracochea, D. .

NEUROPHARMACOLOGY, 2014, 85 :349-356

[28]

Chee MWL, 2008, CURR OPIN NEUROL, V21, P417, DOI 10.1097/WCO.0b013e3283052cf7

[29] Altered effective connectivity of thalamus with vigilance impairments after sleep deprivation [J].

Chen, Yuefan ;

Pan, Leyao ;

Ma, Ning .

JOURNAL OF SLEEP RESEARCH, 2022, 31 (06)

[30] Short-Term Sleep Deprivation Stimulates Hippocampal Neurogenesis in Rats Following Global Cerebral Ischemia/Reperfusion [J].

Cheng, Oumei ;

Li, Rong ;

Zhao, Lei ;

Yu, Lijuan ;

Yang, Bin ;

Wang, Jia ;

Chen, Beibei ;

Yang, Junqing .

PLOS ONE, 2015, 10 (06)

← 1 2 3 4 5 6 7 8 9 10 →