The role of interleukin-15 in the development and treatment of hematological malignancies

被引：15
作者：
Sindaco, Paola [1 ,2 ]
Pandey, Hritisha [1 ]
Isabelle, Colleen [1 ]
Chakravarti, Nitin [1 ,2 ]
Brammer, Jonathan Edward [3 ]
Porcu, Pierluigi [1 ,2 ]
Mishra, Anjali [1 ,2 ,4 ]
机构：
[1] Thomas Jefferson Univ, Sidney Kimmel Canc Ctr, Philadelphia, PA 19144 USA
[2] Thomas Jefferson Univ, Dept Med Oncol, Philadelphia, PA 19144 USA
[3] Ohio State Univ, Dept Internal Med, Columbus, OH USA
[4] Thomas Jefferson Univ, Dept Pharmacol Physiol & Canc Biol, Philadelphia, PA 19144 USA
来源：
FRONTIERS IN IMMUNOLOGY | 2023年 / 14卷
关键词：
IL-15; treatment; blood; cytokine; cancer; ACUTE LYMPHOBLASTIC-LEUKEMIA; NATURAL-KILLER-CELLS; IL-15; TRANS-PRESENTATION; GROWTH-FACTOR; NK CELL; T-CELLS; SOLUBLE IL-15R-ALPHA; ANTITUMOR-ACTIVITY; MYCOSIS-FUNGOIDES; CLINICAL-TRIAL;
D O I：
10.3389/fimmu.2023.1141208
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Cytokines are a vital component of the immune system that controls the activation and growth of blood cells. However, chronic overexpression of cytokines can trigger cellular events leading to malignant transformation. The cytokine interleukin-15 (IL-15) is of particular interest, which has been shown to contribute to the development and progression of various hematological malignancies. This review will provide an overview of the impact of the immunopathogenic function of IL-15 by studying its role in cell survival, proliferation, inflammation, and treatment resistance. We will also review therapeutic approaches for inhibiting IL-15 in blood cancers.
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页数：10
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