Measurement of metoprolol solubility in supercritical carbon dioxide; experimental and modeling study

被引:15
|
作者
Alshahrani, Saad M. [1 ]
Alsubaiyel, Amal M. [2 ]
Abduljabbar, Maram H. [3 ]
Abourehab, Mohammed A. S. [4 ]
机构
[1] Prince Sattam Bin Abdulaziz Univ, Coll Pharm, Dept Pharmaceut, POB 173, Al Kharj 11942, Saudi Arabia
[2] Qassim Univ, Coll Pharm, Dept Pharmaceut, Buraydah 52571, Saudi Arabia
[3] Taif Univ, Coll Pharm, Dept Pharmacol & Toxicol, Taif 21944, Saudi Arabia
[4] Umm Al Qura Univ, Coll Pharm, Dept Pharmaceut, Mecca 21955, Saudi Arabia
关键词
Metoprolol; Supercritical carbon dioxide; Solubility; Empirical models; SOLUTE SOLUBILITY; SOLID DISPERSIONS; DRUGS; BIOAVAILABILITY; CAPECITABINE; TECHNOLOGY; DELIVERY; ASPIRIN;
D O I
10.1016/j.csite.2023.102764
中图分类号
O414.1 [热力学];
学科分类号
摘要
Metoprolol is a beta-blocker agent, widely used to treat hypertension, and some heart diseases. However, due to low bioavailability and short half-life of this drug, the dose and the frequency of its daily use are high, causes to some digestive problems in patients. Designing a new drug delivery system with high efficiency and controlled drug release using a suitable supercritical method can solve these problems. To reach this goal, the solubility of Metoprolol in supercritical CO2 (scCO(2)) should be known. Here, solubility of Metoprolol in supercritical CO2 (scCO(2)) was measured at the pressure and temperature range of 120-300 bar and 308-338 K, respectively. It was determined between the mole fractions of 0.02 x 10(-5) to 8.11 x 10(-5). Also, obtained values were correlated via some well-known empirical models suggested through Kumar- Johnston (K-J), Sung and Shim, Adachi and Lu, Sparks, Bartle, Hozhabr, Khansary, and Jouyban. The empirical model proposed by Adachi and Lu shows the highest correlation precision, with the minimum AARD% of 13.07. Furthermore, the total mixing heat, vaporization enthalpy, and solvation enthalpy of the Metoprolol-scCO(2) binary mixture were obtained as about 107.25 kJ/mol, 115.56 kJ/mol, and -8.31 kJ/mol, respectively.
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页数:9
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