The Role of Mass Spectrometry in Hepatocellular Carcinoma Biomarker Discovery

被引：2

作者：

Shen, Eric Yi-Liang ^{[1
,2
,3
,4
,5
]}

Abellona, U. Mei Ran

Cox, I. Jane ^{[6
,7
]}

Taylor-Robinson, Simon D. ^{[5
]}

机构：

[1] Linkou Chang Gung Mem Hosp, Dept Radiat Oncol, Taoyuan City 333, Taiwan

[2] Linkou Chang Gung Mem Hosp, Proton Therapy Ctr, Taoyuan City 333, Taiwan

[3] Chang Gung Univ, Taoyuan City 333, Taiwan

[4] Linkou Chang Gung Mem Hosp, Clin Metabol Core Lab, Taoyuan City 333, Taiwan

[5] Imperial Coll London, Fac Med, Dept Surg & Canc, London W2 1NY, England

[6] Fdn Liver Res, Roger Williams Inst Hepatol, London SE5 9NT, England

[7] Kings Coll London, Fac Life Sci & Med, London SE5 8AF, England

来源：

METABOLITES | 2023年 / 13卷 / 10期

关键词：

mass spectrometry; biomarkers; hepatocellular carcinoma; metabolomics; DES-GAMMA-CARBOXYPROTHROMBIN; FATTY-ACID-METABOLISM; GLUCOSE-METABOLISM; ALPHA-FETOPROTEIN; SERUM BIOMARKERS; LIVER-CIRRHOSIS; HEPATITIS-B; IDENTIFICATION; METABOLOMICS; CANCER;

D O I：

10.3390/metabo13101059

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hepatocellular carcinoma (HCC) is the main liver malignancy and has a high mortality rate. The discovery of novel biomarkers for early diagnosis, prognosis, and stratification purposes has the potential to alleviate its disease burden. Mass spectrometry (MS) is one of the principal technologies used in metabolomics, with different experimental methods and machine types for different phases of the biomarker discovery process. Here, we review why MS applications are useful for liver cancer, explain the MS technique, and briefly summarise recent findings from metabolomic MS studies on HCC. We also discuss the current challenges and the direction for future research.

引用

页数：13

共 90 条

[1] Optimized Systematic Review Tool: Application to Candidate Biomarkers for the Diagnosis of Hepatocellular Carcinoma [J].

Abellona, Mei Ran ;

Shen, Eric Yi -Liang ;

Cartlidge, Caroline ;

Alkhatib, Alzhraa ;

Thursz, Mark R. ;

Waked, Imam ;

Gomaa, Asmaa I. ;

Holmes, Elaine ;

Sharma, Rohini ;

Taylor-Robinson, Simon D. .

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2022, 31 (07) :1261-1274

[2] Bile acid induces hydrophobicity-dependent membrane alterations [J].

Akare, S ;

Martinez, JD .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2005, 1735 (01) :59-67

[3] Comprehensive and Integrative Genomic Characterization of Hepatocellular Carcinoma [J].

Ally, Adrian ;

Balasundaram, Miruna ;

Carlsen, Rebecca ;

Chuah, Eric ;

Clarke, Amanda ;

Dhalla, Noreen ;

Holt, Robert A. ;

Jones, Steven J. M. ;

Lee, Darlene ;

Ma, Yussanne ;

Marra, Marco A. ;

Mayo, Michael ;

Moore, Richard A. ;

Mungall, Andrew J. ;

Schein, Jacqueline E. ;

Sipahimalani, Payal ;

Tam, Angela ;

Thiessen, Nina ;

Cheung, Dorothy ;

Wong, Tina ;

Brooks, Denise ;

Robertson, A. Gordon ;

Bowlby, Reanne ;

Mungall, Karen ;

Sadeghi, Sara ;

Xi, Liu ;

Covington, Kyle ;

Shinbrot, Eve ;

Wheeler, David A. ;

Gibbs, Richard A. ;

Donehower, Lawrence A. ;

Wang, Linghua ;

Bowen, Jay ;

Gastier-Foster, Julie M. ;

Gerken, Mark ;

Helsel, Carmen ;

Leraas, Kristen M. ;

Lichtenberg, Tara M. ;

Ramirez, Nilsa C. ;

Wise, Lisa ;

Zmuda, Erik ;

Gabriel, Stacey B. ;

Meyerson, Matthew ;

Cibulskis, Carrie ;

Murray, Bradley A. ;

Shih, Juliann ;

Beroukhim, Rameen ;

Cherniack, Andrew D. ;

Schumacher, Steven E. ;

Saksena, Gordon .

CELL, 2017, 169 (07) :1327-+

[4]

Ardrey R.E., 2003, Liquid Chromatography - Mass Spectrometry: An Introduction, P75

[5] Altered Fatty Acid Metabolism-Related Gene Expression in Liver from Morbidly Obese Women with Non-Alcoholic Fatty Liver Disease [J].

Auguet, Teresa ;

Berlanga, Alba ;

Guiu-Jurado, Esther ;

Martinez, Salome ;

Porras, Jose Antonio ;

Aragones, Gemma ;

Sabench, Fatima ;

Hernandez, Merce ;

Aguilar, Carmen ;

Sirvent, Joan Josep ;

Del Castillo, Daniel ;

Richart, Cristobal .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2014, 15 (12) :22173-22187

[6] Lipid metabolic reprogramming in cancer cells [J].

Beloribi-Djefaflia, S. ;

Vasseur, S. ;

Guillaumond, F. .

ONCOGENESIS, 2016, 5 :e189-e189

[7]

Bodzon-Kulakowska A, 2019, WIL SER MASS SPECTR, P217

[8]

Bray F, 2018, CA-CANCER J CLIN, V68, P394, DOI [10.3322/caac.21609, 10.3322/caac.21492]

[9] Increased Lipogenesis, Induced by AKT-mTORC1-RPS6 Signaling, Promotes Development of Human Hepatocellular Carcinoma [J].

Calvisi, Diego F. ;

Wang, Chunmei ;

Ho, Coral ;

Ladu, Sara ;

Lee, Susie A. ;

Mattu, Sandra ;

Destefanis, Giulia ;

Delogu, Salvatore ;

Zimmermann, Antje ;

Ericsson, Johan ;

Brozzetti, Stefania ;

Staniscia, Tommaso ;

Chen, Xin ;

Dombrowski, Frank ;

Evert, Matthias .

GASTROENTEROLOGY, 2011, 140 (03) :1071-U542

[10] Improved spatial resolution in the imaging of biological tissue using desorption electrospray ionization [J].

Campbell, Dahlia I. ;

Ferreira, Christina R. ;

Eberlin, Livia S. ;

Cooks, R. Graham .

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2012, 404 (02) :389-398

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