Programmed cell death pathways as targets for developing antifilarial drugs: Lessons from the recent findings

被引:4
作者
Das, Nabarun Chandra [1 ]
Chakraborty, Pritha [1 ]
Nandy, Samapika [2 ,3 ]
Dey, Abhijit [2 ,5 ]
Malik, Tabarak [4 ]
Mukherjee, Suprabhat [1 ,6 ]
机构
[1] Kazi Nazrul Univ, Dept Anim Sci, Integrat Biochem & Immunol Lab, Asansol, India
[2] Presidency Univ, Dept Life Sci, Kolkata, India
[3] Graph Era Hill Univ, Sch Pharm, Dehra Dun, India
[4] Jimma Univ, Inst Hlth, Jimma, Ethiopia
[5] Presidency Univ, Dept Life Sci, Kolkata, West Bengal, India
[6] Kazi Nazrul Univ, Dept Anim Sci, Integrat Biochem & Immunol Lab, Asansol 713340, West Bengal, India
关键词
apoptosis; drug development; filariasis; oxidative stress; ROS; PARASITE SETARIA-CERVI; WUCHERERIA-BANCROFTI INFECTION; ROS MEDIATED APOPTOSIS; FILARIAL PARASITE; BRUGIA-MALAYI; IN-VITRO; SILVER NANOPARTICLES; ONCHOCERCA-VOLVULUS; OXIDATIVE STRESS; BENZIMIDAZOLE-RESISTANCE;
D O I
10.1111/jcmm.17913
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
More than half a century has passed since the introduction of the National Filariasis Control Program; however, as of 2023, lymphatic filariasis (LF) still prevails globally, particularly in the tropical and subtropical regions, posing a substantial challenge to the objective of worldwide elimination. LF is affecting human beings and its economically important livestock leading to a crucial contributor to morbidities and disabilities. The current scenario has been blowing up alarms of attention to develop potent therapeutics and strategies having efficiency against the adult stage of filarial nematodes. In this context, the exploration of a suitable drug target that ensures lethality to macro and microfilariae is now our first goal to achieve. Apoptosis has been the potential target across all three stages of filarial nematodes viz. oocytes, microfilariae (mf) and adults resulting in filarial death after receiving the signal from the reactive oxygen species (ROS) and executed through intrinsic and extrinsic pathways. Hence, it is considered a leading target for developing antifilarial drugs. Herein, we have shown the efficacy of several natural and synthetic compounds/nanoformulations in triggering the apoptotic death of filarial parasites with little or no toxicity to the host body system.
引用
收藏
页码:2819 / 2840
页数:22
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