Fermented sorghum improves type 2 diabetes remission by modulating gut microbiota and their related metabolites in high fat diet-streptozotocin induced diabetic mice

被引:19
作者
Ofosu, Fred Kwame [1 ]
Elahi, Fazle [1 ,2 ]
Daliri, Eric Banan-Mwine [3 ]
Aloo, Simon Okomo [1 ]
Chelliah, Ramachandran [1 ,4 ]
Han, Sang-Ik [5 ]
Oh, Deog-Hwan [1 ]
机构
[1] Kangwon Natl Univ, Coll Agr & Life Sci, Dept Food Sci & Biotechnol, Chunchon 24341, South Korea
[2] Univ Missouri, Sch Med, Dept Ophthalmol, Columbia, MO USA
[3] Vilnius Univ, Inst Biochem, Life Sci Ctr, Dept Biol Models, Vilnius, Lithuania
[4] Kangwon Natl Univ, Kangwon Inst Inclus Technol KIIT, Dept Food Sci & Biotechnol, Chunchon 24341, Gangwon, South Korea
[5] NICS Upland Crop Breeding Res Div, Dept Southern Area Crop Sci, Gyeongsangnaam 50424, South Korea
关键词
Fermented sorghum; Type; 2; diabetes; Insulin resistance; Gut microbiota; Microbial metabolites; HEALTH;
D O I
10.1016/j.jff.2023.105666
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
Microbial metabolites play key roles in the pathogenesis of insulin resistance and type 2 diabetes (T2D). A preliminary study on the impact of fermented sorghum (FS) on T2D and its modulation of gut microbiota and their metabolites was assessed using 16S rRNA gene sequencing and metabolomics. FS supplementation ameliorated hyperglycemia, insulin resistance and reversed the abundance of opportunistic pathogenic bacteria (such as Oscillibcater, Acetatifactor and Acetivibrio) positively associated with T2D. FS promoted the growth of beneficial bacteria (Muribaculum, Parabacteroides and Phocaeicola) positively correlated with fecal butyrate and propionate inversely associated with T2D. FS decreased the serum concentration of microbial metabolites (pcresol sulfate, indolelactate, indoxyl sulfate, indole-3-aldehyde). FS increased the levels of phenylpropionate, phenyl sulfate, valine, bile acids (taurocholic acid, ursodeoxycholic acid and cholic acid) inversely associated with T2D. The beneficial effect of fermented sorghum on T2D remission could be attributed to modulation of gut microbiota and its related-metabolites.
引用
收藏
页数:16
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