Relevance of mitochondrial alterations in the neurodegenerative diseases, an update and discussion of evidence

被引:0
作者
Aguilar-Gamas, Carlos F. [1 ]
Martinez-Abundis, Eduardo [1 ]
Gomez-Crisostomo, Nancy P. [1 ]
de la Cruz-hernandez, Erick N. [1 ]
机构
[1] Juarez Autonomous Univ Tabasco, Multidisciplinary Acad Div Comalcalco, Lab Res Metab & Infect Dis, Villahermosa, Tabasco, Mexico
来源
REVISTA MEXICANA DE NEUROCIENCIA | 2023年 / 24卷 / 04期
关键词
Neurodegenerative disease; Mitochondrial dysfunction; Alzheimer disease; Parkinson disease; Huntington disease; PARKINSONS-DISEASE; LIPID-PEROXIDATION; OXIDATIVE STRESS; METABOLISM; DYSFUNCTION; APOPTOSIS; CALCIUM;
D O I
10.24875/RMN.23000006
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Neurodegenerative diseases (ND) are undoubtedly part of the more important health issues worldwide. The loss of independence and decreased quality of life are characteristics of these patients that translate into an economic load on relatives and health services. Although myriad factors or metabolic alterations are blamed as causatives, there is a common defect in almost every ND, mitochondrial dysfunction. Mitochondria are the cell's leading energy supplier; therefore, altering its function will affect the cellular function with the energy demand. Defects in mitochondrial mechanisms such as ATP synthesis by the mitochondrial respiratory chain, mitochondrial dynamics, apoptosis regulation, and oxidative stress are described as part of the pathological characteristics of Alzheimer's, Parkinson's, Huntington's diseases, and Amyotrophic Lateral Sclerosis. In this review, we will briefly describe the mitochondrial roles in cell life before analyzing the recently published bibliography that addresses the mitochondrial dysfunction and mitochondrial mechanisms implicated in ND and will discuss a relevant question in the field: is mitochondrial dysfunction a cause or consequence for these diseases?
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页码:117 / 125
页数:9
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