Ketogenic Diet Combined with Moderate Aerobic Exercise Training Ameliorates White Adipose Tissue Mass, Serum Biomarkers, and Hepatic Lipid Metabolism in High-Fat Diet-Induced Obese Mice

被引:5
作者
Yan, Jiabao [1 ]
Ren, Cuiru [1 ]
Dong, Yunlong [1 ]
Wali, Jibran A. A. [2 ]
Song, Hongjie [1 ]
Zhang, Ying [1 ]
Zhang, Hengrui [3 ]
Kou, Guangning [1 ]
Raubenheimer, David [1 ,2 ]
Cui, Zhenwei [1 ]
机构
[1] Zhengzhou Univ, Ctr Sport Nutr & Hlth, Ctr Nutr Ecol, Sch Phys Educ main campus, Zhengzhou 450001, Peoples R China
[2] Univ Sydney, Charles Perkins Ctr, Sydney, NSW 2006, Australia
[3] Zhengzhou Univ Light Ind, Sch Phys Educ, Zhengzhou 450002, Peoples R China
基金
中国博士后科学基金;
关键词
ketogenic diet; aerobic exercise; lipid metabolism; obesity; DE-NOVO LIPOGENESIS; LONG-TERM; RESISTANCE EXERCISE; ENERGY-EXPENDITURE; WEIGHT-LOSS; PPAR-ALPHA; STEATOSIS; INTENSITY; LIVER; OVERWEIGHT;
D O I
10.3390/nu15010251
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Obesity is a serious public health issue worldwide. Growing evidence demonstrates the efficacy of the ketogenic diet (KD) for weight loss, but there may be some adverse side effects such as dyslipidemia and hepatic steatosis. Aerobic exercise is a widely recognized approach for improving these metabolic markers. Here we explored the combined impacts of KD and moderate aerobic exercise for an 8-week intervention on body weight and fat loss, serum biomarkers, and hepatic lipid metabolism in a mouse model of high-fat diet-induced obesity. Both KD and KD combined with exercise significantly reduced body weight and fat mass. No significant adverse effects of KD were observed in serum biomarkers or hepatic lipid storage, except for an increase in circulating triglyceride level. However, aerobic exercise lowered serum triglyceride levels, and further ameliorated serum parameters, and hepatic steatosis in KD-fed mice. Moreover, gene and protein expression analysis indicated that KD combined with exercise was associated with increased expression of lipolysis-related genes and protein levels, and reduced expression of lipogenic genes relative to KD without exercise. Overall, our findings for mice indicate that further work on humans might reveal that KD combined with moderate aerobic exercise could be a promising therapeutic strategy for obesity.
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页数:17
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