Quantifying the impact of unmeasured confounding in observational studies with the E value

被引：27

作者：

Gaster, Tobias ^{[1
]}

Eggertsen, Christine Marie ^{[1
]}

Stovring, Henrik ^{[2
,3
]}

Ehrenstein, Vera ^{[4
,5
]}

Petersen, Irene ^{[4
,5
,6
]}

机构：

[1] Aarhus Univ, Aarhus, Denmark

[2] Steno Diabet Ctr Aarhus, Aarhus, Denmark

[3] Univ Southern Denmark, Clin Pharmacol Pharm & Environm Med, Odense, Denmark

[4] Aarhus Univ, Dept Clin Epidemiol, DK-8000 Aarhus, Denmark

[5] Aarhus Univ Hosp, Aarhus, Denmark

[6] UCL, Dept Primary Care & Populat Hlth, London, England

来源：

BMJ MEDICINE | 2023年 / 2卷 / 01期

关键词：

Pregnancy complications; Epidemiology; Obstetrics; SEROTONIN REUPTAKE INHIBITORS; SENSITIVITY-ANALYSIS; MISCARRIAGE; PREGNANCY; RISK;

D O I：

10.1136/bmjmed-2022-000366

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The E value method deals with unmeasured confounding, a key source of bias in observational studies. The E value method is described and its use is shown in a worked example of a meta-analysis examining the association between the use of antidepressants in pregnancy and the risk of miscarriage.

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页数：5

相关论文

共 23 条

[1]

Ajinkya Shaunak, 2013, Ind Psychiatry J, V22, P37, DOI 10.4103/0972-6748.123615

[2] Increasing use of antidepressants in pregnancy [J].

Cooper, William O. ;

Willy, Mary E. ;

Pont, Stephen J. ;

Ray, Wayne A. .

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2007, 196 (06) :544-545

[3] On causation in therapeutic research: Observational studies, randomised experiments and instrumental variable analysis [J].

Dekkers, Olaf M. .

PREVENTIVE MEDICINE, 2011, 53 (4-5) :239-241

[4] Sensitivity Analysis Without Assumptions [J].

Ding, Peng ;

VanderWeele, Tyler J. .

EPIDEMIOLOGY, 2016, 27 (03) :368-377

[5] Making inferences on treatment effects from real world data: propensity scores, confounding by indication, and other perils for the unwary in observational research [J].

Freemantle, Nick ;

Marston, Louise ;

Walters, Kate ;

Wood, John ;

Reynolds, Matthew R. ;

Petersen, Irene .

BMJ-BRITISH MEDICAL JOURNAL, 2013, 347

[6] Using Big Data to Emulate a Target Trial When a Randomized Trial Is Not Available [J].

Hernan, Miguel A. ;

Robins, James M. .

AMERICAN JOURNAL OF EPIDEMIOLOGY, 2016, 183 (08) :758-764

[7] Use of real-world evidence from healthcare utilization data to evaluate drug safety during pregnancy [J].

Huybrechts, Krista F. ;

Bateman, Brian T. ;

Hernandez-Diaz, Sonia .

PHARMACOEPIDEMIOLOGY AND DRUG SAFETY, 2019, 28 (07) :906-922

[8] Maternal Use of Selective Serotonin Reuptake Inhibitors and Risk of Miscarriage - Assessing Potential Biases [J].

Johansen, Rie Laurine Rosenthal ;

Mortensen, Laust Hvas ;

Andersen, Anne-Marie Nybo ;

Hansen, Anne Vinkel ;

Strandberg-Larsen, Katrine .

PAEDIATRIC AND PERINATAL EPIDEMIOLOGY, 2015, 29 (01) :72-81

[9]

Kestenbaum B., 2019, Epidemiology and Biostatistics, DOI DOI 10.1007/978-3-319-97433-0_2

[10] Glucocorticoid use and risk of suicide: a Danish population-based case-control study [J].

Laugesen, Kristina ;

Farkas, Dora Kormendine ;

Vestergaard, Mogens ;

Jorgensen, Jens Otto Lunde ;

Petersen, Irene ;

Sorensen, Henrik Toft .

WORLD PSYCHIATRY, 2021, 20 (01) :142-143