Self-Assembled Lenalidomide/AIE Prodrug Nanobomb for Tumor Imaging and Cancer Therapy

被引：1

作者：

Mai, Zhijian ^{[1
,2
]}

Cao, Nengjie ^{[1
,2
]}

Cheng, Erzhuo ^{[3
,4
]}

Zeng, Zhiwen ^{[1
,2
]}

Feng, Yancong ^{[1
,2
]}

Wang, Yao ^{[1
,2
]}

French, Paddy J. ^{[5
]}

Lee, Yi-Kuen ^{[6
,7
]}

Yang, Haihong ^{[8
]}

Yang, Bin ^{[3
,4
]}

Li, Hao ^{[1
,2
]}

Zhou, Guofu ^{[1
,2
]}

机构：

[1] South China Normal Univ, Inst Elect Paper Displays, South China Acad Adv Optoelect, Guangdong Prov Key Lab Opt Informat Mat & Technol, R China, Guangzhou 510006, Peoples R China

[2] South China Normal Univ, Natl Ctr Int Res Green Optoelect, Guangzhou 510006, Peoples R China

[3] Guangzhou Med Univ, Affiliated Hosp 6, Qingyuan Peoples Hosp, Guangzhou 511436, Peoples R China

[4] Guangzhou Med Univ, Sch Biomed Engn, Guangzhou 511436, Peoples R China

[5] Delft Univ Technol, BE Lab, EWI, NL-2628 CD Delft, Netherlands

[6] Hong Kong Univ Sci & Technol, Dept Mech & Aerosp Engn, Kowloon, Hong Kong 999077, Peoples R China

[7] Hong Kong Univ Sci & Technol, Dept Elect & Comp Engn, Kowloon, Hong Kong 999077, Peoples R China

[8] Guangzhou Med Univ, Affiliated Hosp 1, Dept Thorac Oncol, State Key Lab Resp Dis, Guangzhou 510006, Peoples R China

来源：

ACS APPLIED NANO MATERIALS | 2023年 / 6卷 / 21期

基金：

中国国家自然科学基金;

关键词：

small-molecule prodrug; Schiff base linkage; aggregation-induced emission; self-assembly; tumor-targeteddiagnosis and therapy; SMALL-MOLECULE PRODRUG; FLUORESCENCE; STRATEGIES; MECHANISM; DESIGN;

D O I：

10.1021/acsanm.3c03611

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

To develop multifunctional small-molecule prodrugs is highly desirable for cancer treatment but remains challenging in intrinsic traceability. As an acid-cleavable linkage, a Schiff bases benefiting from its distinctive fluorescence quenching ability was selected to prepare a small-molecule prodrug with cancer-targeted and self-indicating. In this study, we designed and developed a multifunctional self-assembled nanobomb of amphiphilic TPE-Lenalidomide prodrug, which comprises a hydrophobic aggregation-induced emission (AIE) probe 4-(1,2,2-triphenylvinyl)benzaldehyde (TPE-CHO) and a hydrophilic anticancer drug Lenalidomide via a Schiff base linkage. We investigated the synergistic effect of d-PET and C=N isomerization which would keep the fluorescence of TPE-Lenalidomide in the "always off" state by density functional theory (DFT) calculation. Once reaching the pathological site, such a vesicular nanobomb of TPE-Lenalidomide will be acidolyzed to release the AIE probe and Lenalidomide molecules simultaneously, consequently realizing high-efficiency effects of tumor imaging and cancer therapy (cell viability: normal cell L929, similar to 79.49%; cancer cell 4T1, similar to 27.08%; p = 0.000118). This work may pave an avenue to prepare small-molecule prodrugs for tumor-targeted diagnosis and cancer therapy.

引用

页码：19807 / 19817

页数：11

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