Inflammatory Blood Biomarkers Are Associated with Long-Term Clinical Disease Severity in Parkinson's Disease

被引：13

作者：

Hepp, Dagmar H. ^{[1
,2
,3
]}

van Wageningen, Thecla A. ^{[1
,3
]}

Kuiper, Kirsten L. ^{[1
,3
]}

van Dijk, Karin D. ^{[4
]}

Oosterveld, Linda P. ^{[1
,3
]}

Berendse, Henk W. ^{[2
,3
]}

van de Berg, Wilma D. J. ^{[1
,3
]}

机构：

[1] Amsterdam UMC Locat Vrije Univ Amsterdam, Dept Anat & Neurosci, de Boelelaan 1108, NL-1081 HZ Amsterdam, Netherlands

[2] Amsterdam UMC Locat Vrije Univ Amsterdam, Dept Neurol, de Boelelaan 1117, NL-1081 HZ Amsterdam, Netherlands

[3] Amsterdam UMC Locat Vrije Univ Amsterdam, Program Neurodegenerat, Amsterdam Neurosci, NL-1081 HZ Amsterdam, Netherlands

[4] Stichting Epilepsie Instellingen Nederland SEIN, Sleep Wake Ctr, NL-2103 SW Heemstede, Netherlands

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 19期

关键词：

immune response; blood biomarkers; Parkinson's disease; disease severity; CCL23; TGF-alpha; TNFRSF9; MILD COGNITIVE IMPAIRMENT; GROWTH-FACTOR; T-CELLS; CEREBROSPINAL-FLUID; ALZHEIMERS-DISEASE; ALPHA; PROGRESSION; PROFILE; EXPRESSION; DECLINE;

D O I：

10.3390/ijms241914915

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An altered immune response has been identified as a pathophysiological factor in Parkinson's disease (PD). We aimed to identify blood immunity-associated proteins that discriminate PD from controls and that are associated with long-term disease severity in PD patients. Immune response-derived proteins in blood plasma were measured using Proximity Extension Technology by OLINK in a cohort of PD patients (N = 66) and age-matched healthy controls (N = 52). In a selection of 30 PD patients, we evaluated changes in protein levels 7-10 years after the baseline and assessed correlations with motor and cognitive assessments. Data from the Parkinson's Disease Biomarkers Program (PDBP) cohort and the Parkinson's Progression Markers Initiative (PPMI) cohort were used for independent validation. PD patients showed an altered immune response compared to controls based on a panel of four proteins (IL-12B, OPG, CXCL11, and CSF-1). The expression levels of five inflammation-associated proteins (CCL23, CCL25, TNFRSF9, TGF-alpha, and VEGFA) increased over time in PD and were partially associated with more severe motor and cognitive symptoms at follow-up. Increased CCL23 levels were associated with cognitive decline and the APOE4 genotype. Our findings provide further evidence for an altered immune response in PD that is associated with disease severity in PD over a long period of time.

引用

页数：14

共 53 条

[31] Interleukin (IL)-1 beta, IL-2, IL-4, IL-6 and transforming growth factor-alpha levels are elevated in ventricular cerebrospinal fluid in juvenile parkinsonism and Parkinson's disease [J].