Association between circ_0004365 and cisplatin resistance in esophageal squamous cell carcinoma

被引：2

作者：

Yamada, Moyuru ^{[1
]}

Tanaka, Koji ^{[1
]}

Yamamoto, Kenichi ^{[2
]}

Matsumoto, Hisatake ^{[3
]}

Yamasaki, Makoto ^{[1
]}

Yamashita, Kotaro ^{[1
]}

Makino, Tomoki ^{[1
]}

Saito, Takuro ^{[1
]}

Yamamoto, Kazuyoshi ^{[1
]}

Takahashi, Tsuyoshi ^{[1
]}

Kurokawa, Yukinori ^{[1
]}

Nakajima, Kiyokazu ^{[1
]}

Okada, Yukinori ^{[2
]}

Eguchi, Hidetoshi ^{[1
]}

Doki, Yuichiro ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Med, Dept Gastroenterol Surg, Suita, Osaka 5650871, Japan

[2] Osaka Univ, Grad Sch Med, Dept Stat Genet, Suita, Osaka 5650871, Japan

[3] Osaka Univ, Grad Sch Med, Dept Traumatol & Acute Crit Med, Suita, Osaka 5650871, Japan

来源：

ONCOLOGY LETTERS | 2023年 / 26卷 / 05期

关键词：

esophageal squamous cell carcinoma; circular RNA; cisplatin; RNA-sequencing; CIRCexplorer; CIRCULAR RNAS; GASTRIC-CANCER; MECHANISMS; EXPRESSION; PROMOTES; INVASION;

D O I：

10.3892/ol.2023.14054

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cisplatin is one of the most predominant drugs for the chemotherapy of esophageal squamous cell carcinoma (ESCC); however, the underlying resistance mechanisms are still almost unknown. The present study performed RNA sequencing of human circular RNA (circRNA) in TE11 cells and cisplatin-resistant TE11 cells (TE11R). The expression profiles determined using CIRCexplorer2 revealed that the expression of circ_0004365, mapped on the Semaphorin 3C gene, was significantly greater in TE11R compared with in TE11. In reverse transcription-quantitative PCR, circ_0004365 expression was observed in human ESCC and non-tumor tissues and was significantly upregulated in ESCC tumor tissues after chemotherapy. Circ_0004365 expression was significantly upregulated in patients with poor pathological response (P=0.02). Furthermore, patients with advanced pT stage showed an upregulation in circ_0004365 expression after chemotherapy (P=0.02). The MTT assay revealed that knockdown of circ_0003465 in TE11 significantly decreased resistance to cisplatin. In conclusion, the present study suggested that circ_0004365 was associated with cisplatin resistance in ESCC and can be used as both a novel biomarker and a therapeutic target.

引用

页数：10

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