Synthesis, Characterization, and Antibacterial Activity of Novel 2,3-Dihydroxyquinoxaline-5-carboxamide Derivatives

The quinoxaline-5-carboxamide derivatives (Vq-Vu) and (VIa-Vu) were prepared using methyl-2,3-diamino benzoate as the starting material. Analytical and spectral data were used to characterize the synthesized compounds. Four bacterial strains-Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pyogenes-were tested with titled compounds. Fluoro-substituted, phenethyl groups, oxygenated cyclic and aliphatic, and benzonitrile are among the reported derivatives that demonstrated good inhibition for antibacterial activity, while the rest compounds shown equipotent to moderate action. Using commercially available 2,3-diamino benzoate 1 as the starting material, innovative 2,3-dimethoxyquinoxaline-5-carboxamide derivatives (Vq-Vu) and 2,3-dihydroyquinoxaline-5-carboxamide derivatives (VIa-VIu) were synthesised in five stages. The electronegative group on the quinoxaline moiety boosts the antibacterial properties of the produced compounds, according to the results of SAR.