Gut Microbiota and Plasma Bile Acids Associated with Non-Alcoholic Fatty Liver Disease Resolution in Bariatric Surgery Patients

被引:6
|
作者
Perez-Rubio, Alvaro [1 ]
Soluyanova, Polina [2 ,3 ]
Moro, Erika [2 ,3 ]
Quintas, Guillermo [4 ]
Rienda, Ivan [5 ]
Perianez, Maria Dolores [1 ]
Painel, Andres [6 ]
Vizuete, Jose [6 ]
Perez-Rojas, Judith [5 ]
Castell, Jose V. [2 ,3 ,7 ]
Trullenque-Juan, Ramon [1 ]
Pareja, Eugenia [2 ]
Jover, Ramiro [2 ,3 ,7 ]
机构
[1] Hosp Univ Dr Peset, Serv Cirugia Gen & Aparato Digest, Valencia 46017, Spain
[2] La Fe Univ Valencia, Hlth Res Inst, Expt Hepatol Joint Unit, Valencia 46026, Spain
[3] Univ Valencia, Dept Bioquim Biol Mol, Valencia 46010, Spain
[4] Leitat Technol Ctr, Hlth & Biomed, Terrassa 08225, Spain
[5] Hosp Univ Politecn La Fe, Dept Pathol, Valencia 46026, Spain
[6] Hosp Univ Dr Peset, Sect Abdominal Imaging, Dept Radiol, Valencia 46017, Spain
[7] Inst Salud Carlos III, CIBERehd, Madrid 28029, Spain
关键词
NAFLD resolution; gut microbiota; bile acid; bariatric surgery; morbid obesity; Hospital Universitario Dr. PesetBacteroides; Akkermansia; STEATOSIS; STEATOHEPATITIS; ACTIVATION; FIBROSIS; OBESE; NAFLD;
D O I
10.3390/nu15143187
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Bariatric surgery (BS) has several benefits, including resolution of non-alcoholic fatty liver disease (NAFLD) in many patients. However, a significant percentage of patients do not experience improvement in fatty liver after BS, and more than 10% develop new or worsening NAFLD features. Therefore, a question that remains unanswered is why some patients experience resolved NAFLD after BS and others do not. In this study, we investigated the fecal microbiota and plasma bile acids associated with NAFLD resolution in twelve morbidly obese patients undergoing BS, of whom six resolved their steatosis one year after surgery and another six did not. Results indicate that the hallmark of the gut microbiota in responder patients is a greater abundance of Bacteroides, Akkermansia, and several species of the Clostridia class (genera: Blautia, Faecalibacterium, Roseburia, Butyricicoccusa, and Clostridium), along with a decreased abundance of Actinomycetes/Bifidobacterium and Faecalicatena. NAFLD resolution was also associated with a sustained increase in primary bile acids (particularly non-conjugated), which likely results from a reduction in bacterial gut species capable of generating secondary bile acids. We conclude that there are specific changes in gut microbiota and plasma bile acids that could contribute to resolving NAFLD in BS patients. The knowledge acquired can help to design interventions with prebiotics and/or probiotics to promote a gut microbiome that favors NAFLD resolution.
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页数:17
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