Advanced central nervous system imaging biomarkers in radiologically isolated syndrome: a mini review

被引：1
作者：
Collorone, Sara [1 ]
Foster, Michael A. A. [1 ]
Toosy, Ahmed T. T. [1 ]
机构：
[1] UCL, UCL Queen Sq Inst Neurol, Fac Brain Sci, Queen Sq MS Ctr,Dept Neuroinflammat, London, England
来源：
FRONTIERS IN NEUROLOGY | 2023年 / 14卷
关键词：
multiple sclerosis; magnetic resonance imaging; optical coherence tomography; connectivity; neurodegeneration; radiologically isolated syndrome; OPTICAL COHERENCE TOMOGRAPHY; CENTRAL VEIN SIGN; MULTIPLE-SCLEROSIS; BRAIN ATROPHY; WHITE-MATTER; DEGENERATION; CONVERSION; ONSET; MRI;
D O I：
10.3389/fneur.2023.1172807
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Radiologically isolated syndrome is characterised by central nervous system white-matter hyperintensities highly suggestive of multiple sclerosis in individuals without a neurological history of clinical demyelinating episodes. It probably represents the pre-symptomatic phase of clinical multiple sclerosis but is poorly understood. This mini review summarises our current knowledge regarding advanced imaging techniques in radiologically isolated syndrome that provide insights into its pathobiology and prognosis. The imaging covered will include magnetic resonance imaging-derived markers of central nervous system volumetrics, connectivity, and the central vein sign, alongside optical coherence tomography-related metrics.
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