Immune response in blood before and after epileptic and psychogenic non-epileptic seizures

被引：8

作者：

Ahl, Matilda ^{[1
,2
,3
]}

Taylor, Marie K. ^{[1
,2
,3
]}

Avdic, Una ^{[1
,2
,3
]}

Lundin, Anna ^{[1
,2
]}

Andersson, My ^{[1
,2
,3
]}

Amandusson, Asa ^{[4
]}

Kumlien, Eva ^{[5
]}

Strandberg, Maria Compagno ^{[6
]}

Ekdahl, Christine T. ^{[1
,2
,3
]}

机构：

[1] Lund Univ, Div Clin Neurophysiol, Lund, Sweden

[2] Lund Univ, Dept Clin Sci, Lund, Sweden

[3] Lund Univ, Lund Epilepsy Ctr, Dept Clin Sci, Lund, Sweden

[4] Uppsala Univ, Dept Med Sci, Clin Neurophysiol, Uppsala, Sweden

[5] Uppsala Univ, Dept Med Sci, Uppsala, Sweden

[6] Lund Univ, Dept Clin Sci, Div Neurol, Lund, Sweden

来源：

HELIYON | 2023年 / 9卷 / 03期

基金：

瑞典研究理事会;

关键词：

Epilepsy; Psychogenic non -epileptic seizure; EEG; Immune response; Biomarker; Interleukin-6; INTERLEUKIN-1 RECEPTOR ANTAGONIST; CEREBROSPINAL-FLUID; CYTOKINES; IL-6; MECHANISMS; EXPRESSION; DIAGNOSIS; IMPACT;

D O I：

10.1016/j.heliyon.2023.e13938

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Inflammatory processes may provoke epileptic seizures and seizures may promote an immune reaction. Hence, the systemic immune reaction is a tempting diagnostic and prognostic marker in epilepsy. We explored the immune response before and after epileptic and psychogenic non -epileptic seizures (PNES). Serum samples collected from patients with videoEEG-verified tem-poral or frontal lobe epilepsy (TLE or FLE) or TLE + PNES showed increased interleukin-6 (IL-6) levels in between seizures (interictally), compared to controls. Patients with PNES had no in-crease in IL-6. The IL-6 levels increased transiently even further within hours after a seizure (postictally) in TLE but not in FLE patients. The postictal to interictal ratio of additionally five immune factors were also increased in TLE patients only. We conclude that immune factors have the potential to be future biomarkers for epileptic seizures and that the heterogeneity among different epileptic and non-epileptic seizures may be disclosed in peripheral blood sampling in-dependent of co-morbidities.

引用

页数：10

共 50 条

[1] Psychogenic Non-Epileptic Seizures
Chen, David K.
Sharma, Esha
LaFrance, W. Curt, Jr.
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS, 2017, 17 (09)
[2] Psychogenic non-epileptic seizures
Doss, Robert C.
LaFrance, W. Curt, Jr.
EPILEPTIC DISORDERS, 2016, 18 (04) : 337 - 343
[3] Psychogenic non-epileptic seizures in children
Agarwal, Rajkumar
Gathers-Hutchins, Latisha
Stephanou, Hara
CURRENT PROBLEMS IN PEDIATRIC AND ADOLESCENT HEALTH CARE, 2021, 51 (07)
[4] Psychogenic non-epileptic seizures: A challenging entity
Sahaya, Kinshuk
Dholakia, Swapan A.
Sahota, Pradeep K.
JOURNAL OF CLINICAL NEUROSCIENCE, 2011, 18 (12) : 1602 - 1607
[5] The Comparison Between Neuropsychological Features of Psychogenic Non-epileptic Seizures and Epileptic Seizures
Oji, Bahare
Zibadi, Hamide Ajam
Roozbeh, Mahrooz
Simani, Leila
Noorbala, Ahmad Ali
Arbabi, Mohammad
ARCHIVES OF NEUROSCIENCE, 2021, 8 (03)
[6] Non-epileptic psychogenic seizures
González-Goizueta, E
Martínez-Pérez, B
Mauri-Llerda, JA
REVISTA DE NEUROLOGIA, 2002, 35 (10) : 954 - 959
[7] Epilepsy in patients with psychogenic non-epileptic seizures
Marchetti, Renato Luiz
Kurcgant, Daniela
Gallucci-Neto, Jose
Von Bismark, Mary Ann
Fiore, Lia Arno
ARQUIVOS DE NEURO-PSIQUIATRIA, 2010, 68 (02) : 168 - 173
[8] Psychogenic non-epileptic seizures (PNES)
Hingray, C.
Biberon, J.
El-Hage, W.
de Toffol, B.
REVUE NEUROLOGIQUE, 2016, 172 (4-5) : 263 - 269
[9] Ictal injury in psychogenic non-epileptic seizures
Asadi-Pooya, Ali A.
Emami, Mehrdad
Emami, Yasaman
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, 2014, 23 (05): : 363 - 366
[10] Psychogenic non-epileptic seizures in clinical practice
Gugala-Iwaniuk, Magdalena
Bochynska, Anna
Sienkiewicz-Jarosz, Halina
AKTUALNOSCI NEUROLOGICZNE, 2022, 22 (01): : 17 - 24

← 1 2 3 4 5 →