The role of ferroptosis in neurodegenerative diseases

被引：27

作者：

Xu, Yunfei ^{[1
,2
,3
]}

Zhao, Jie ^{[4
]}

Zhao, Yao ^{[1
,2
,3
]}

Zhou, Lin ^{[1
,2
,3
]}

Qiao, Haoduo ^{[1
,2
,3
]}

Xu, Qing ^{[1
,2
,3
]}

Liu, Ying ^{[1
,2
,3
]}

机构：

[1] Cent South Univ, Xiangya Sch Med, Dept Pathophysiol, Changsha 410008, Hunan, Peoples R China

[2] Sepsis Translat Med Key Lab Hunan Prov, Changsha 410008, Hunan, Peoples R China

[3] Cent South Univ, Natl Med Funct Expt Teaching Ctr, Changsha 410078, Hunan, Peoples R China

[4] Cent South Univ, Xiangya Hosp, Dept Neurosurg, Changsha 410008, Hunan, Peoples R China

来源：

MOLECULAR BIOLOGY REPORTS | 2023年 / 50卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Ferroptosis; Neurodegenerative diseases; Alzheimer's disease; Parkinson's disease; Huntington's disease; Amyotrophic lateral sclerosis; GLUTATHIONE-PEROXIDASE; 4; BRAIN FERRITIN IRON; PARKINSONS-DISEASE; OXIDATIVE STRESS; CELL-DEATH; HUNTINGTONS-DISEASE; LIPID-PEROXIDATION; ALZHEIMERS-DISEASE; SUBSTANTIA-NIGRA; ALPHA-SYNUCLEIN;

D O I：

10.1007/s11033-022-08048-y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ferroptosis is newly identified as a non-apoptotic form of programmed cell death. It is characterized by iron-dependent intracellular accumulation of lipid peroxides which ultimately leads to oxidative stress and cell death. Ferroptosis has been identified in several diseases, such as cancer, renal failure, liver injury, and ischemia-reperfusion injury. Besides, it has been reported to be involved in the pathological mechanism of neurodegenerative diseases (NDD). In addition, interventions targeting ferroptosis can influence the course of NDD, making it a potential therapeutic target for NDD. By summarizing the current research on ferroptosis and its impact on many neurological diseases, we hope to provide valuable strategies for the underlying mechanisms and treatment of these neurological diseases.

引用

页码：1655 / 1661

页数：7

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