The role of ferroptosis in neurodegenerative diseases

被引：24
作者：
Xu, Yunfei [1 ,2 ,3 ]
Zhao, Jie [4 ]
Zhao, Yao [1 ,2 ,3 ]
Zhou, Lin [1 ,2 ,3 ]
Qiao, Haoduo [1 ,2 ,3 ]
Xu, Qing [1 ,2 ,3 ]
Liu, Ying [1 ,2 ,3 ]
机构：
[1] Cent South Univ, Xiangya Sch Med, Dept Pathophysiol, Changsha 410008, Hunan, Peoples R China
[2] Sepsis Translat Med Key Lab Hunan Prov, Changsha 410008, Hunan, Peoples R China
[3] Cent South Univ, Natl Med Funct Expt Teaching Ctr, Changsha 410078, Hunan, Peoples R China
[4] Cent South Univ, Xiangya Hosp, Dept Neurosurg, Changsha 410008, Hunan, Peoples R China
来源：
MOLECULAR BIOLOGY REPORTS | 2023年 / 50卷 / 02期
基金：
中国国家自然科学基金;
关键词：
Ferroptosis; Neurodegenerative diseases; Alzheimer's disease; Parkinson's disease; Huntington's disease; Amyotrophic lateral sclerosis; GLUTATHIONE-PEROXIDASE; 4; BRAIN FERRITIN IRON; PARKINSONS-DISEASE; OXIDATIVE STRESS; CELL-DEATH; HUNTINGTONS-DISEASE; LIPID-PEROXIDATION; ALZHEIMERS-DISEASE; SUBSTANTIA-NIGRA; ALPHA-SYNUCLEIN;
D O I：
10.1007/s11033-022-08048-y
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Ferroptosis is newly identified as a non-apoptotic form of programmed cell death. It is characterized by iron-dependent intracellular accumulation of lipid peroxides which ultimately leads to oxidative stress and cell death. Ferroptosis has been identified in several diseases, such as cancer, renal failure, liver injury, and ischemia-reperfusion injury. Besides, it has been reported to be involved in the pathological mechanism of neurodegenerative diseases (NDD). In addition, interventions targeting ferroptosis can influence the course of NDD, making it a potential therapeutic target for NDD. By summarizing the current research on ferroptosis and its impact on many neurological diseases, we hope to provide valuable strategies for the underlying mechanisms and treatment of these neurological diseases.
引用
收藏
页码：1655 / 1661
页数：7
相关论文
共 106 条
  • [1] Quantitative Susceptibility MRI to Detect Brain Iron in Amyotrophic Lateral Sclerosis
    Acosta-Cabronero, Julio
    Machts, Judith
    Schreiber, Stefanie
    Abdulla, Susanne
    Kollewe, Katja
    Petri, Susanne
    Spotorno, Nicola
    Kaufmann, Joern
    Heinze, Hans-Jochen
    Dengler, Reinhard
    Vielhaber, Stefan
    Nestor, Peter J.
    [J]. RADIOLOGY, 2018, 289 (01) : 195 - 203
  • [2] Clinical staging in amyotrophic lateral sclerosis: analysis of Edaravone Study 19
    Al-Chalabi, Ammar
    Chio, Adriano
    Merrill, Charlotte
    Oster, Gerry
    Bornheimer, Rebecca
    Agnese, Wendy
    Apple, Stephen
    [J]. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2021, 92 (02) : 165 - 171
  • [3] Frontal lobe dysfunction in progressive supranuclear palsy: Evidence for oxidative stress and mitochondrial impairment
    Albers, DS
    Augood, SJ
    Park, LCH
    Browne, SE
    Martin, DM
    Adamson, J
    Hutton, M
    Standaert, DG
    Vonsattel, JPG
    Gibson, GE
    Beal, MF
    [J]. JOURNAL OF NEUROCHEMISTRY, 2000, 74 (02) : 878 - 881
  • [4] Selenium Drives a Transcriptional Adaptive Program to Block Ferroptosis and Treat Stroke
    Alim, Ishraq
    Caulfield, Joseph T.
    Chen, Yingxin
    Swarup, Vivek
    Geschwind, Daniel H.
    Ivanova, Elena
    Seravalli, Javier
    Ai, Youxi
    Sensing, Lauren H.
    Ste Marie, Emma J.
    Hondal, Robert J.
    Mukherjee, Sushmita
    Cave, John W.
    Sagdullaev, Botir T.
    Karuppagounder, Saravanan S.
    Ratan, Rajiv R.
    [J]. CELL, 2019, 177 (05) : 1262 - +
  • [5] Anderson Karen E, 2011, Handb Clin Neurol, V100, P15, DOI 10.1016/B978-0-444-52014-2.00002-1
  • [6] Glutathione dysregulation and the etiology and progression of human diseases
    Ballatori, Nazzareno
    Krance, Suzanne M.
    Notenboom, Sylvia
    Shi, Shujie
    Tieu, Kim
    Hammond, Christine L.
    [J]. BIOLOGICAL CHEMISTRY, 2009, 390 (03) : 191 - 214
  • [7] Bartzokis G, 2000, CELL MOL BIOL, V46, P821
  • [8] Brain ferritin iron as a risk factor for age at onset in neurodegenerative diseases
    Bartzokis, G
    Tishler, TA
    Shin, IS
    Lu, PH
    Cummings, JL
    [J]. REDOX-ACTIVE METALS IN NEUROLOGICAL DISORDERS, 2004, 1012 : 224 - 236
  • [9] Increased basal ganglia iron levels in Huntington disease
    Bartzokis, G
    Cummings, J
    Perlman, S
    Hance, DB
    Mintz, J
    [J]. ARCHIVES OF NEUROLOGY, 1999, 56 (05) : 569 - 574
  • [10] Brain ferritin iron may influence age- and gender-related risks of neurodegeneration
    Bartzokis, George
    Tishler, Todd A.
    Lu, Po H.
    Villablanca, Pablo
    Altshuler, Lori L.
    Carter, Michele
    Huang, Danny
    Edwards, Nancy
    Mintz, Jim
    [J]. NEUROBIOLOGY OF AGING, 2007, 28 (03) : 414 - 423
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